Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0T2LP
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| Former ID |
DIB000734
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| Drug Name |
ARM036
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| Synonyms |
ALADORIAN; UNII-PJ5KSA836G; PJ5KSA836G; 865433-00-7; ARM036; Aladorian [USAN:INN]; Aladorian (USAN/INN); S44121-1; SCHEMBL3423110; CHEMBL2104951; DTXSID40235657; FPWBHFYYVSNIFZ-UHFFFAOYSA-N; s44121; D10304; (7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)oxoacetic acid; 1,4-Benzothiazepine-4(5H)-acetic acid, 2,3-dihydro-7-methoxy-alpha-oxo-; 2-(7-Methoxy-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)-2-oxoacetic acid
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| Drug Type |
Small molecular drug
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| Indication | Heart failure [ICD-11: BD10-BD13; ICD-10: I50, I50.9; ICD-9: 428] | Discontinued in Phase 2 | [1] | |
| Company |
Armgo pharma
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| Structure |
 |
Download2D MOL |
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| Formula |
C12H13NO4S
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| Canonical SMILES |
COC1=CC2=C(C=C1)SCCN(C2)C(=O)C(=O)O
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| InChI |
1S/C12H13NO4S/c1-17-9-2-3-10-8(6-9)7-13(4-5-18-10)11(14)12(15)16/h2-3,6H,4-5,7H2,1H3,(H,15,16)
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| InChIKey |
FPWBHFYYVSNIFZ-UHFFFAOYSA-N
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| CAS Number |
CAS 865433-00-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Ryanodine receptor 1 (RYR1) | Target Info | Modulator | [2] |
| Panther Pathway | Beta1 adrenergic receptor signaling pathway | |||
| Beta2 adrenergic receptor signaling pathway | ||||
| CCKR signaling map ST | ||||
| Reactome | Stimuli-sensing channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034371) | |||
| REF 2 | The Ryanodine Receptor Stabilizer S44121 / Arm036 Improves Peripheral and Respiratory Muscle Function in a Mouse Model of Heart Failure. Circulation. 2014; 130: A13726. | |||
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