Drug Information
Drug General Information | Top | |||
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Drug ID |
D0SR4G
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Former ID |
DIB005924
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Drug Name |
ONT-093
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Synonyms |
MDR inhibitors, Ontogen; OC-144-093
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Drug Type |
Small molecular drug
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Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Discontinued in Phase 1 | [1] | |
Company |
Ontogen Corp
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Structure |
Download2D MOL |
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Formula |
C32H38N4O
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Canonical SMILES |
CCOCC=CC1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=C(C=C3)NC(C)C)C4=CC=C(C=C4)NC(C)C
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InChI |
1S/C32H38N4O/c1-6-37-21-7-8-24-9-11-27(12-10-24)32-35-30(25-13-17-28(18-14-25)33-22(2)3)31(36-32)26-15-19-29(20-16-26)34-23(4)5/h7-20,22-23,33-34H,6,21H2,1-5H3,(H,35,36)/b8-7+
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InChIKey |
RSJCLODJSVZNQA-BQYQJAHWSA-N
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CAS Number |
CAS 216227-54-2
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Multidrug resistance protein 1 (ABCB1) | Target Info | Inhibitor | [2] |
KEGG Pathway | ABC transporters | |||
Bile secretion | ||||
MicroRNAs in cancer | ||||
NetPath Pathway | IL2 Signaling Pathway | |||
TCR Signaling Pathway | ||||
Pathway Interaction Database | HIF-1-alpha transcription factor network | |||
Reactome | ABC-family proteins mediated transport | |||
WikiPathways | Nuclear Receptors in Lipid Metabolism and Toxicity | |||
Abacavir transport and metabolism | ||||
Multi Drug Resistance Protein 1 (Glycoprotein 1) Regulation | ||||
Integrated Pancreatic Cancer Pathway | ||||
Allograft Rejection | ||||
Drug Induction of Bile Acid Pathway | ||||
Codeine and Morphine Metabolism |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011621) | |||
REF 2 | A phase I pharmacokinetic study of the P-glycoprotein inhibitor, ONT-093, in combination with paclitaxel in patients with advanced cancer. Invest New Drugs. 2005 Aug;23(4):311-5. |
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