Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0S0HA
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| Former ID |
DIB015019
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| Drug Name |
O6-Benzylguanine alkylade
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| Synonyms |
KRX-0402; O6-Benzylguanine (BG)
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| Indication | Sarcoma [ICD-11: 2A60-2C35; ICD-10: C81-C86; ICD-9: 202.8] | Phase 3 | [1], [2] | |
| Company |
Wiley-Liss; Keryx Biopharmaceuticals
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| Structure |
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Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | O-6-methylguanine-DNA-alkyltransferase (MGMT) | Target Info | Modulator | [1], [2] |
| WikiPathways | DNA Damage Reversal | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. J Clin Oncol. 2009 Mar 10;27(8):1262-7. | |||
| REF 2 | Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol. 2005 Oct 1;23(28):7178-87. | |||
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