Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Q7RE
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| Former ID |
DNC006944
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| Drug Name |
AZD-1152-HQPA
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| Synonyms |
Barasertib
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C26H30FN7O3
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| Canonical SMILES |
CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO
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| InChI |
1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)
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| InChIKey |
QYZOGCMHVIGURT-UHFFFAOYSA-N
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| CAS Number |
CAS 722544-51-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
24383544, 26579845, 37130963, 50100089, 56464737, 99437002, 103502389, 103905345, 121279826, 124757034, 125163838, 125415399, 126581752, 126639841, 126666997, 126738601, 131480706, 134339066, 134344149, 135686204, 135686205, 135686220, 135686221, 136340105, 136367334, 136368071, 136920279, 138025211, 143498128, 144115662, 152239918, 152258093, 160646932, 162011398, 162037468, 162202568, 163118529, 163177446, 163642560, 163907926, 164045132, 164193988, 164199875, 164339425, 172087025, 172659381, 174006408, 174530488, 178102291, 180186528
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| ChEBI ID |
CHEBI:91367
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Phase I study of barasertib (AZD1152), a selective inhibitor of Aurora B kinase, in patients with advanced solid tumors.Invest New Drugs.2013 Apr;31(2):370-80. | |||
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