Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0P1IX
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| Former ID |
DIB005485
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| Drug Name |
OT-551
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| Synonyms |
Tempol-H prodrug, Othera
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| Drug Type |
Small molecular drug
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| Indication | Ocular inflammation [ICD-11: 9C61.24; ICD-10: H40.4; ICD-9: 370.33] | Phase 2 | [1] | |
| Company |
Othera Pharmaceuticals Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C13H23NO3
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| Canonical SMILES |
CC1(CC(CC(N1O)(C)C)OC(=O)C2CC2)C
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| InChI |
1S/C13H23NO3/c1-12(2)7-10(8-13(3,4)14(12)16)17-11(15)9-5-6-9/h9-10,16H,5-8H2,1-4H3
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| InChIKey |
ZWEXEKJLDHNLLA-UHFFFAOYSA-N
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| CAS Number |
CAS 627085-11-4
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nuclear factor erythroid 2-related factor 2 (Nrf2) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Protein processing in endoplasmic reticulum | |||
| NetPath Pathway | IL5 Signaling Pathway | |||
| WikiPathways | Oxidative Stress | |||
| Transcriptional activation by NRF2 | ||||
| NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | ||||
| Aryl Hydrocarbon Receptor Pathway | ||||
| Mesodermal Commitment Pathway | ||||
| Aryl Hydrocarbon Receptor | ||||
| Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis | ||||
| Arylhydrocarbon receptor (AhR) signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00306488) OT-551 Antioxidant Eye Drops to Treat Geographic Atrophy in Age-Related Macular Degeneration. U.S. National Institutes of Health. | |||
| REF 2 | New hope for dry AMD. Nat Rev Drug Discov. 2013 Jul;12(7):501-2. | |||
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