Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0OA5G
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| Former ID |
DCL000006
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| Drug Name |
SNS-314
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| Synonyms |
SN-314
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Therapeutic Class |
Anticancer Agents
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| Company |
Sunesis Pharma
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| Structure |
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Download2D MOL |
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| Formula |
C18H15ClN6OS2
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| Canonical SMILES |
C1=CC(=CC(=C1)Cl)NC(=O)NC2=NC=C(S2)CCNC3=NC=NC4=C3SC=C4
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| InChI |
1S/C18H15ClN6OS2/c19-11-2-1-3-12(8-11)24-17(26)25-18-21-9-13(28-18)4-6-20-16-15-14(5-7-27-15)22-10-23-16/h1-3,5,7-10H,4,6H2,(H,20,22,23)(H2,21,24,25,26)
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| InChIKey |
FAYAUAZLLLJJGH-UHFFFAOYSA-N
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| CAS Number |
CAS 1057249-41-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
56464763, 57654852, 80963129, 99443832, 103905586, 123092438, 124950687, 134338722, 135298932, 135685410, 135685411, 135685429, 137884076, 152344036, 160968444, 162772363, 177748743, 180387003, 185985029, 198969974, 202829292, 229434728, 246827038, 252216324, 252443026, 252450737, 252481011, 252543353
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| ChEBI ID |
CHEBI:94720
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00519662) Safety and Tolerability Study of SNS-314 for Advanced Solid Tumors. U.S. National Institutes of Health. | |||
| REF 2 | SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17. | |||
| REF 3 | The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model. Mol Cancer Ther. 2009 Apr;8(4):930-9. | |||
| REF 4 | Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Jan-Feb;31(1):47-57. | |||
| REF 5 | Water-soluble prodrugs of an Aurora kinase inhibitor. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1409-12. | |||
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