Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0NV9O
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| Former ID |
DIB000122
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| Drug Name |
BAY 10-00394
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| Synonyms |
roniciclib; BAY 1000394; BAY 10-00394; KB-145902; 1223498-69-8; Tube010; SCHEMBL875845; GTPL7874
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| Drug Type |
Small molecular drug
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| Indication | Small-cell lung cancer [ICD-11: 2C25.Y; ICD-9: 162.9] | Discontinued in Phase 2 | [1], [2] | |
| Company |
Bayer healthcare pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C18H21F3N4O3S
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| Canonical SMILES |
CC(C(C)OC1=NC(=NC=C1C(F)(F)F)NC2=CC=C(C=C2)S(=N)(=O)C3CC3)O
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| InChI |
1S/C18H21F3N4O3S/c1-10(26)11(2)28-16-15(18(19,20)21)9-23-17(25-16)24-12-3-5-13(6-4-12)29(22,27)14-7-8-14/h3-6,9-11,14,22,26H,7-8H2,1-2H3,(H,23,24,25)/t10-,11-,29?/m1/s1
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| InChIKey |
UELYDGOOJPRWGF-MFOHZAOFSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7874). | |||
| REF 2 | BAY 1000394, a novel cyclin-dependent kinase inhibitor, with potent antitumor activity in mono- and in combination treatment upon oral application. Mol Cancer Ther. 2012 Oct;11(10):2265-73. | |||
| REF 3 | National Cancer Institute Drug Dictionary (drug id 770319). | |||
| REF 4 | Liposarcoma: molecular genetics and therapeutics. Sarcoma. 2011;2011:483154. | |||
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