Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0MP0X
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| Former ID |
DNCL002157
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| Drug Name |
AZD1480
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| Synonyms |
RET inhibitors
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| Drug Type |
Small molecular drug
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| Indication | Myeloproliferative syndrome [ICD-11: 2A22; ICD-10: D47.1] | Phase 2 | [1], [2] | |
| Company |
AstraZeneca
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| Structure |
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Download2D MOL |
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| Formula |
C14H14ClFN8
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| Canonical SMILES |
CC1=CC(=NN1)NC2=NC(=NC=C2Cl)NC(C)C3=NC=C(C=N3)F
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| InChI |
1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
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| InChIKey |
PDOQBOJDRPLBQU-QMMMGPOBSA-N
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| CAS Number |
CAS 935666-88-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
26519886, 29130416, 30501377, 103162110, 104247312, 104253491, 124757619, 124950690, 125085303, 125164423, 135727415, 135727828, 136367464, 136368069, 137275853, 144115664, 152258114, 152344082, 160646953, 162011702, 162037792, 162202677, 163642940, 163908010, 164042060, 164194010, 170481613, 178102556, 180418429, 184816716, 198974218, 210024100, 223705186, 224223235, 229369513, 244377667, 249816444, 251916047, 251917395, 251962983, 251967016, 252441842, 252451671
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5933). | |||
| REF 2 | The Janus kinases inhibitor AZD1480 attenuates growth of small cell lung cancers in vitro and in vivo. Clin Cancer Res. 2013 Dec 15;19(24):6777-86. | |||
| REF 3 | The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell. 2009 Dec 8;16(6):487-97. | |||
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