Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0ML0L
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| Former ID |
DNCL003495
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| Drug Name |
ARRY-614
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| Synonyms |
Pexmetinib; 945614-12-0; ARRY-614; Pexmetinib (ARRY-614); UNII-3750D0U8B5; 3750D0U8B5; Pexmetinib [INN]; Pexmetinib;ARRY-614; Pexmetinib(ARRY-614); ARRY614; SCHEMBL379035; GTPL9917; MolPort-039-193-822; LNMRSSIMGCDUTP-UHFFFAOYSA-N; BCP28410; EX-A1421; s7799; ZINC41747181; AKOS032945154; SB16914; Urea, N-(3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-N'-((5-fluoro-2-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)phenyl)methyl)-
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| Drug Type |
Small molecular drug
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| Indication | Arthritis [ICD-11: FA20] | Discontinued in Phase 1 | [1] | |
| Myelodysplastic syndrome [ICD-11: 2A37] | Discontinued in Phase 1 | [1] | ||
| Company |
Array BioPharma
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| Structure |
 |
Download2D MOL |
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| Formula |
C31H33FN6O3
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| Canonical SMILES |
CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NCC3=C(C=CC(=C3)F)OC4=CC5=C(C=C4)N(N=C5)CCO
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| InChI |
1S/C31H33FN6O3/c1-20-5-8-24(9-6-20)38-29(17-28(36-38)31(2,3)4)35-30(40)33-18-22-15-23(32)7-12-27(22)41-25-10-11-26-21(16-25)19-34-37(26)13-14-39/h5-12,15-17,19,39H,13-14,18H2,1-4H3,(H2,33,35,40)
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| InChIKey |
LNMRSSIMGCDUTP-UHFFFAOYSA-N
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| CAS Number |
CAS 945614-12-0
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiopoietin 1 receptor (TEK) | Target Info | Modulator | [2] |
| Stress-activated protein kinase (p38) | Target Info | Modulator | [2] | |
| KEGG Pathway | Ras signaling pathway | |||
| Rap1 signaling pathway | ||||
| HIF-1 signaling pathway | ||||
| PI3K-Akt signaling pathway | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | Wnt Signaling Pathway | |||
| Panther Pathway | Angiogenesis | |||
| Pathway Interaction Database | Angiopoietin receptor Tie2-mediated signaling | |||
| SHP2 signaling | ||||
| Reactome | Tie2 Signaling | |||
| RAF/MAP kinase cascade | ||||
| WikiPathways | Wnt Signaling Pathway Netpath | |||
| Cell surface interactions at the vascular wall | ||||
| Angiogenesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026289) | |||
| REF 2 | Cmpany report (Arraybiopharma) | |||
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