Drug General Information
Drug ID
D0LU4N
Former ID
DIB014261
Drug Name
EGFRvIII CAR
Indication Glioblastoma multiforme [ICD-11: 2A00.0; ICD-9: 191] Phase 1/2 [1]
Company
Kite pharma santa monica; national cancer institute
Target and Pathway
Target(s) Epidermal growth factor receptor variant III (EGFR vIII) Target Info Modulator [2]
References
REF 1 ClinicalTrials.gov (NCT01454596) CAR T Cell Receptor Immunotherapy Targeting EGFRvIII for Patients With Malignant Gliomas Expressing EGFRvIII. U.S. National Institutes of Health.
REF 2 EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss. Clin Cancer Res. 2014 Feb 15;20(4):972-84.

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