Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0K0EK
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| Former ID |
DNC001146
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| Drug Name |
Prasterone
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| Synonyms |
Dehydroepiandrosterone; DHEA; 53-43-0; PRASTERONE; Dehydroisoandrosterone; Androstenolone; trans-Dehydroandrosterone; Psicosterone; Diandrone; Diandron; 3beta-hydroxyandrost-5-en-17-one; 17-Hormoforin; Prestara; 17-Chetovis; Andrestenol; 5-Dehydroepiandrosterone; Intrarosa; Siscelar plus; 5,6-Didehydroisoandrosterone; Dehydro-epi-androsterone; Prasteronum; 5,6-Dehydroisoandrosterone; Prasterona; Epiandrosterone, 5-dehydro-; Caswell No 051F; 5,6-Dehydroisoandrostorone
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| Drug Type |
Small molecular drug
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| Indication | Chronic obstructive pulmonary disease [ICD-11: CA22; ICD-10: J44, J44.9] | Approved | [1] | |
| Cardiovascular disease [ICD-11: BA00-BE2Z; ICD-10: I00-I99] | Phase 4 | [2], [3] | ||
| Structure |
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Download2D MOL |
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| Formula |
C19H28O2
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| Canonical SMILES |
CC12CCC3C(C1CCC2=O)CC=C4C3(CCC(C4)O)C
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| InChI |
1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1
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| InChIKey |
FMGSKLZLMKYGDP-USOAJAOKSA-N
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| CAS Number |
CAS 53-43-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
1983, 4449, 75250, 596018, 837865, 841442, 3135651, 7885884, 8145544, 8153636, 11446567, 12014907, 12146065, 14751238, 14775640, 17404931, 24278369, 24702275, 26703947, 29224908, 46387028, 46508824, 47193749, 47959958, 48413520, 48415849, 49681751, 49747225, 49857278, 50172721, 53777474, 53788218, 56312069, 56312916, 56313484, 56313819, 56320669, 56320670, 57323014, 87566797, 91692812, 92297484, 92303742, 92308678, 92309040, 92709895, 93167098, 96025095, 103302695, 104095449
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| ChEBI ID |
CHEBI:28689
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| ADReCS Drug ID | BADD_D02446 | |||
| SuperDrug ATC ID |
A14AA07
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| SuperDrug CAS ID |
cas=000053430
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Direct agonist/antagonist functions of dehydroepiandrosterone. Endocrinology. 2005 Nov;146(11):4568-76. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2370). | |||
| REF 3 | ClinicalTrials.gov (NCT02357472) The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders. U.S. National Institutes of Health. | |||
| REF 4 | Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity. Ageing Res Rev. 2004 Apr;3(2):171-87. | |||
| REF 5 | Glucose utilization and activity of glucose-6-phosphate dehydrogenase, isocitrate dehydrogenase and malate dehydrogenase in rat erythrocytes after treatment with tuberculostatic agents. Vopr Med Khim. 1986 Sep-Oct;32(5):32-5. | |||
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