Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0IQ7Y
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| Former ID |
DIB020648
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| Drug Name |
PBIT
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| Synonyms |
2514-30-9; PBIT; 2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one; 2-(4-methylphenyl)-1,2-benzothiazol-3-one; MLS000583746; 2-(p-Tolyl)benzo[d]isothiazol-3(2H)-one; 2-(p-tolyl)-1,2-benzothiazol-3-one; SMR000200989; 2-(4-methylphenyl)-1,2-benzothiazol-3(2H)-one; 1,2-Benzisothiazol-3(2H)-one, 2-(4-methylphenyl)-; 2-(4-methylphenyl)-2,3-dihydro-1,2-benzothiazol-3-one; ChemDiv3_007090; AC1LIP69; cid_935415; SCHEMBL2443755; GTPL7026; CHEMBL1336959; CTK0J4356; BDBM34737; AOB6896; DTXSID10359056; MolPort-002-285-696; HMS2576N21
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C14H11NOS
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| Canonical SMILES |
CC1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3S2
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| InChI |
1S/C14H11NOS/c1-10-6-8-11(9-7-10)15-14(16)12-4-2-3-5-13(12)17-15/h2-9H,1H3
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| InChIKey |
KRXMYBAZKJBJAB-UHFFFAOYSA-N
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| CAS Number |
CAS 2514-30-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3666350, 4808878, 9205796, 11232806, 14770407, 17433179, 44887175, 48243154, 49927446, 50122649, 50307905, 56373497, 57287617, 85817937, 89328628, 92182799, 92708914, 110082725, 125055410, 128425920, 131277728, 138814238, 162489300, 163667341, 163737341, 170485694, 178103605, 179199536, 223404300, 228554531, 252451528, 252554253, 252617385
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Lysine-specific demethylase 5A (KDM5A) | Target Info | Inhibitor | [1] |
| Lysine-specific demethylase 5B (KDM5B) | Target Info | Inhibitor | [1] | |
| Lysine-specific demethylase 5C (KDM5C) | Target Info | Inhibitor | [1] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29;288(13):9408-17. | |||
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