Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0IQ6P
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| Former ID |
DCL001168
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| Drug Name |
Cabozantinib
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| Synonyms |
Cabometyx; Cometriq
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| Drug Type |
Small molecular drug
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| Indication | Thyroid cancer [ICD-11: 2D10; ICD-10: C73; ICD-9: 193] | Approved | [1], [2] | |
| Ovarian cancer [ICD-11: 2C73; ICD-10: C56] | Phase 2 | [1], [2] | ||
| Company |
Exelixis
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| Structure |
 |
Download2D MOL |
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| Formula |
C28H24FN3O5
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| Canonical SMILES |
COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F
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| InChI |
1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
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| InChIKey |
ONIQOQHATWINJY-UHFFFAOYSA-N
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| CAS Number |
CAS 849217-68-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
103932275, 117695999, 131480693, 135267839, 135626782, 135727427, 136367316, 136368016, 136920380, 137256574, 137276008, 137760418, 143499870, 144115772, 152234431, 152258418, 160647254, 160676622, 160962864, 162011361, 162037456, 162202657, 164023425, 164041945, 164837657, 172914677, 174530916, 175266754, 178102511, 185997013, 198993077, 202543085, 223387911, 224083495, 226693608, 244920971, 249737079, 249896088, 252088620, 252110119, 252158839, 252215083, 252439619, 252451817, 252543409
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| ChEBI ID |
CHEBI:72317
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| ADReCS Drug ID | BADD_D00330 ; BADD_D00331 | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5887). | |||
| REF 2 | Clinical pipeline report, company report or official report of Exelixis (2011). | |||
| REF 3 | Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. | |||
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