Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0H2UB
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| Former ID |
DAP001031
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| Drug Name |
Suramin
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| Synonyms |
Antrypol; Belganyl; Farma; Fourneau; Germanin; Moranyl; Naganil; Naganin; Naganine; Naganol; Naphuride; SVR; Suramine; SURAMIN SODIUM; Sodium suramin; Suramine sodium; Farma 939; Naganol 6 Na; Germanin (TN); SGCTO-001
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| Drug Type |
Small molecular drug
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| Indication | African trypanosomiasis [ICD-11: 1F51; ICD-10: B56, B56.9; ICD-9: 86.5] | Phase 1 | [1], [2] | |
| Therapeutic Class |
Antinematodal Agents
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| Company |
Bayer Pharmaceuticals Corporation
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| Structure |
 |
Download2D MOL |
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| Formula |
C51H40N6O23S6
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| Canonical SMILES |
CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)C
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| InChI |
1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)
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| InChIKey |
FIAFUQMPZJWCLV-UHFFFAOYSA-N
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| CAS Number |
CAS 145-63-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10175, 544513, 595952, 841306, 5325056, 7890636, 8024358, 8024470, 8153296, 11341933, 11362116, 11364809, 11367371, 11369933, 11371568, 11374912, 11378100, 11487518, 11490540, 11493061, 11495691, 14709929, 14792752, 24770262, 24875087, 26697081, 26756673, 29224413, 46488321, 46491094, 46507013, 47291251, 47440394, 49996875, 53789045, 57280266, 57322738, 80234645, 85209323, 103190607, 103975506, 104309017, 124634028, 124892421, 124892422, 125086901, 126687992, 127316601, 127316602, 127316603
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| ChEBI ID |
CHEBI:45906
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| SuperDrug ATC ID |
P01CX02
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| SuperDrug CAS ID |
cas=000129464
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Follicle-stimulating hormone receptor (FSHR) | Target Info | Antagonist | [3], [4] |
| Heparanase (HPSE) | Target Info | Inhibitor | [1], [2] | |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Ovarian steroidogenesis | ||||
| Glycosaminoglycan degradation | ||||
| Metabolic pathways | ||||
| Proteoglycans in cancer | ||||
| Pathwhiz Pathway | Vasopressin Regulation of Water Homeostasis | |||
| Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone | ||||
| Pathway Interaction Database | Syndecan-1-mediated signaling events | |||
| Reactome | Hormone ligand-binding receptors | |||
| G alpha (s) signalling events | ||||
| HS-GAG degradation | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Ovarian Infertility Genes | ||||
| Peptide GPCRs | ||||
| FSH signaling pathway | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| Glycosaminoglycan metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1728). | |||
| REF 2 | Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40. | |||
| REF 3 | Suramin: clinical uses and structure-activity relationships. Mini Rev Med Chem. 2008 Nov;8(13):1384-94. | |||
| REF 4 | Follicle stimulating hormone receptor (FSHR) antagonist and epithelial ovarian cancer (EOC). J Exp Ther Oncol. 2007;6(3):201-4. | |||
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