Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0E1QI
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| Former ID |
DIB020997
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| Drug Name |
SU11274
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| Synonyms |
Met kinase Inhibitor; SU-11274
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C28H30ClN5O4S
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| Canonical SMILES |
CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)C=C3C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O
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| InChI |
1S/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13-34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37,38)33(4)20-7-5-6-19(29)14-20/h5-9,14-16,30H,10-13H2,1-4H3,(H,31,35)/b23-16-
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| InChIKey |
FPYJSJDOHRDAMT-KQWNVCNZSA-N
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| CAS Number |
CAS 658084-23-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14720363, 16865465, 22395876, 23984869, 24724625, 26759130, 29217660, 44692626, 57372718, 78782302, 85286099, 91722392, 99302720, 99436971, 103566217, 123051067, 124756984, 125163789, 126658547, 126726633, 131344572, 131408367, 131480750, 134964429, 136340172, 136367282, 136367776, 138602656, 139030286, 143496650, 152133983, 152237702, 152344163, 162011450, 162037422, 162202651, 163687719, 164043002, 172914483, 175607420, 177748770, 178101751, 179694511, 180438587, 186014494, 187071977, 204369725, 223377267, 223678026, 223705038
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Receptor tyrosine kinases as therapeutic targets: the model of the MET oncogene. Curr Drug Targets. 2001 Mar;2(1):41-55. | |||
| REF 2 | Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion. Mol Cancer Ther. 2003 Nov;2(11):1085-92. | |||
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