Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0C0JT
|
|||
| Former ID |
DNC003303
|
|||
| Drug Name |
Nimesulide
|
|||
| Synonyms |
nimesulide; 51803-78-2; N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide; Mesulid; Flogovital; Sulidene; Nimed; R-805; 4-NITRO-2-PHENOXYMETHANESULFONANILIDE; Nisulid; Nimesulidum [INN-Latin]; Nimesulida [INN-Spanish]; R 805; UNII-V4TKW1454M; 4-Nitro-2-phenoxy-methanesulfonanilide; 4'-Nitro-2'-phenoxymethanesulfonanilide; Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)-; EINECS 257-431-4; 4'-Nitro-2'-phenoxymethansulfonanilid; BRN 2421175; CHEMBL56367; MLS000069680; V4TKW1454M; Methanesulfonanilide, 4'-nitro-2'-phenoxy-; CHEBI:44445; Dulanermin
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Metastatic colorectal cancer [ICD-11: 2B91; ICD-10: C19] | Terminated | [1] | |
| Non-hodgkin lymphoma [ICD-11: 2B33.5; ICD-10: C85.9] | Terminated | [1] | ||
| Non-small-cell lung cancer [ICD-11: 2C25.Y] | Terminated | [1] | ||
| Structure |
 |
Download2D MOL |
||
| Formula |
C13H12N2O5S
|
|||
| Canonical SMILES |
CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2
|
|||
| InChI |
1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3
|
|||
| InChIKey |
HYWYRSMBCFDLJT-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 51803-78-2
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
855635, 5912186, 6436673, 7404099, 7848112, 7889413, 7980127, 8149946, 8152768, 10321585, 11111520, 11111521, 11121727, 11122207, 11335868, 11361107, 11362857, 11364471, 11365419, 11367033, 11367981, 11369595, 11370925, 11370926, 11372711, 11373582, 11373834, 11376143, 11377757, 11462079, 11466222, 11467342, 11485118, 11485804, 11489357, 11491391, 11491993, 11495391, 12012650, 14752054, 17405416, 24277576, 24278583, 26612437, 26680139, 26697157, 26746940, 26746941, 26751468, 29215000
|
|||
| ChEBI ID |
CHEBI:44445
|
|||
| SuperDrug ATC ID |
M01AX17; M02AA26
|
|||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
|
Studied Microbe: Ruminococcus torques
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Nimesulide (adjusted p-values: 1.02E-03). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of Genentech (2011). | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 3 | Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. | |||
| REF 4 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.