Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B2GI
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| Former ID |
DAP000132
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| Drug Name |
Glimepiride
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| Synonyms |
Amarel; Amaryl; Endial; Glimepirid; Glimepirida; Glimepiridum; Glimepride; Glimer; Glymepirid; Roname; Solosa; Glimepirida [Spanish]; Glimepiridum [Latin]; Sandoz glimepiride; HOE 490; Amaryl (TN); Hoe-490; Novo-glimepiride; PMS-glimepiride; Ratio-glimepiride; Amaryl, Glista OD, Glimepiride; Glimepiride [USAN:BAN:INN]; Glimepiride (JAN/USP/INN); 1-((p-(2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl)phenyl)sulfonyl)-3-(trans-4-methylcyclohexyl)urea; 1-{[4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]amino}ethyl)phenyl]sulfonyl}-3-(trans-4-methylcyclohexyl)urea; 3-ethyl-4-methyl-N-[2-(4-{[(trans-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide; 3-ethyl-4-methyl-n-(4-(n-((1r,4r)-4-methylcyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro; 4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide; 64598P
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| Drug Type |
Small molecular drug
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| Indication | Diabetic complication [ICD-11: 5A2Y; ICD-9: 253.5, 588.1] | Approved | [1], [2] | |
| Therapeutic Class |
Hypoglycemic Agents
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| Company |
Sanofi-Aventis
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H34N4O5S
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| Canonical SMILES |
CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
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| InChI |
1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)
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| InChIKey |
WIGIZIANZCJQQY-UHFFFAOYSA-N
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| CAS Number |
CAS 261361-60-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9871, 5043708, 7847659, 7979409, 8145852, 8152210, 11112876, 11466679, 11467799, 11486338, 12013623, 14908413, 24895093, 26719876, 26755029, 26755030, 29222609, 32963623, 46386690, 46508842, 47589079, 47959862, 48155569, 48185080, 48334594, 49648856, 49699123, 49731995, 49835734, 50037704, 50126308, 56313637, 57321825, 77374551, 81040871, 81092812, 85787655, 85787837, 91613422, 92125647, 92308643, 92309214, 92711714, 99344865, 99437102, 103394534, 103543151, 103913636, 104171333, 104303626
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| ChEBI ID |
CHEBI:5383
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| ADReCS Drug ID | BADD_D01023 | |||
| SuperDrug ATC ID |
A10BB12
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| SuperDrug CAS ID |
cas=093479971
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | ATP-binding cassette transporter C8 (ABCC8) | Target Info | Blocker | [3] |
| ATP-binding cassette transporter C9 (ABCC9) | Target Info | Blocker | [3] | |
| KEGG Pathway | ABC transporters | |||
| Insulin secretion | ||||
| Type II diabetes mellitus | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Pancreas Function | ||||
| Pathway Interaction Database | FOXA2 and FOXA3 transcription factor networks | |||
| Reactome | ABC-family proteins mediated transport | |||
| Regulation of insulin secretion | ||||
| WikiPathways | Potassium Channels | |||
| Integration of energy metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6820). | |||
| REF 2 | Clinical utilization of combined rosiglitazone and glimepiride in the treatment of type 2 diabetes mellitus. Orv Hetil. 2007 Dec 9;148(49):2331-5. | |||
| REF 3 | Mechanism of disopyramide-induced hypoglycaemia in a patient with Type 2 diabetes. Diabet Med. 2009 Jan;26(1):76-8. | |||
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