Drug General Information
Drug ID
D0AZ3C
Former ID
DAP000179
Drug Name
Imatinib
Synonyms
Cgp 57148; Glamox; Glamox (TN); Gleevec (TN); Glivec (TN); Imatinib (INN); Imatinib (STI571); Imatinib Methansulfonate; Imatinib [INN:BAN]; 112GI019; 152459-95-5; BKJ8M8G5HI; CCRIS 9076; CGP-57148; CHEMBL941; Imatinib free base; STI; UNII-BKJ8M8G5HI
Drug Type
Small molecular drug
Indication Chronic myelogenous leukaemia [ICD-11: 2A20.0; ICD-10: C92.1; ICD-9: 205.1] Approved [1], [2]
Intestinal cancer [ICD-11: 2C0Z] Phase 3 [1], [2]
Lung cancer [ICD-11: 2C25.0] Phase 2 [1], [2]
Systemic mastocytosis [ICD-11: 2A21.0; ICD-9: 202.6, 757.33] Investigative [3]
Therapeutic Class
Anticancer Agents
Company
Novartis AG
Structure
Download
2D MOL

3D MOL

Formula
C29H31N7O
InChI
1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
InChIKey
KTUFNOKKBVMGRW-UHFFFAOYSA-N
CAS Number
CAS 152459-95-5
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:45783
SuperDrug ATC ID
L01XE01
SuperDrug CAS ID
cas=152459955
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Fusion protein Bcr-Abl (Bcr-Abl) Target Info Inhibitor [4]
Mcl-1 messenger RNA (MCL-1 mRNA) Target Info . [3]
Platelet-derived growth factor receptor (PDGFR) Target Info Inhibitor [4]
Tyrosine-protein kinase Kit (KIT) Target Info Inhibitor [4]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Hematopoietic cell lineage
Melanogenesis
Pathways in cancer
Acute myeloid leukemia
Central carbon metabolism in cancer
NetPath Pathway IL3 Signaling Pathway
IL4 Signaling Pathway
KitReceptor Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)
Reactome PIP3 activates AKT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
WikiPathways Kit receptor signaling pathway
Differentiation Pathway
Signaling by SCF-KIT
PIP3 activates AKT signaling
Cardiac Progenitor Differentiation
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
REF 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5687).
REF 2 Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19.
REF 3 Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.
REF 4 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.

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