| Target and Pathway |
Top |
| Target(s) |
cAMP protein kinase type II-beta (PRKAR2B) |
Target Info
|
Inhibitor |
[1] |
| Epidermal growth factor receptor (EGFR) |
Target Info
|
Inhibitor |
[1] |
| Extracellular signal-regulated kinase 2 (ERK2) |
Target Info
|
Inhibitor |
[1] |
| FGFR4 messenger RNA (FGFR4 mRNA) |
Target Info
|
Inhibitor |
[1] |
| Fibroblast growth factor receptor 1 (FGFR1) |
Target Info
|
Inhibitor |
[1] |
| Fibroblast growth factor receptor 2 (FGFR2) |
Target Info
|
Inhibitor |
[1] |
| Fibroblast growth factor receptor 3 (FGFR3) |
Target Info
|
Inhibitor |
[1] |
| Fungal Protein kinase A (Fung ypkA) |
Target Info
|
Inhibitor |
[1] |
| Fyn tyrosine protein kinase (FYN) |
Target Info
|
Inhibitor |
[1] |
| Platelet-derived growth factor receptor alpha (PDGFRA) |
Target Info
|
Inhibitor |
[1] |
| Platelet-derived growth factor receptor beta (PDGFRB) |
Target Info
|
Inhibitor |
[1] |
| PRKACA messenger RNA (PRKACA mRNA) |
Target Info
|
Inhibitor |
[1] |
| Vascular endothelial growth factor receptor 2 (KDR) |
Target Info
|
Inhibitor |
[1] |
|
KEGG Pathway
|
MAPK signaling pathway
|
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Ras signaling pathway
|
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Rap1 signaling pathway
|
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Endocytosis
|
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PI3K-Akt signaling pathway
|
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Signaling pathways regulating pluripotency of stem cells
|
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Regulation of actin cytoskeleton
|
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Pathways in cancer
|
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MicroRNAs in cancer
|
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Bladder cancer
|
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Central carbon metabolism in cancer
|
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Calcium signaling pathway
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Cytokine-cytokine receptor interaction
|
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Focal adhesion
|
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Gap junction
|
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HTLV-I infection
|
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Glioma
|
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Prostate cancer
|
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Melanoma
|
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Choline metabolism in cancer
|
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VEGF signaling pathway
|
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Proteoglycans in cancer
|
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cAMP signaling pathway
|
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Chemokine signaling pathway
|
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Oocyte meiosis
|
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Apoptosis
|
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Adrenergic signaling in cardiomyocytes
|
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Vascular smooth muscle contraction
|
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Wnt signaling pathway
|
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Hedgehog signaling pathway
|
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Platelet activation
|
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Circadian entrainment
|
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Long-term potentiation
|
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Retrograde endocannabinoid signaling
|
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Glutamatergic synapse
|
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Cholinergic synapse
|
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Serotonergic synapse
|
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GABAergic synapse
|
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Dopaminergic synapse
|
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Olfactory transduction
|
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Taste transduction
|
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Inflammatory mediator regulation of TRP channels
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Insulin signaling pathway
|
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Insulin secretion
|
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GnRH signaling pathway
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Ovarian steroidogenesis
|
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Progesterone-mediated oocyte maturation
|
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Estrogen signaling pathway
|
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Melanogenesis
|
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Thyroid hormone synthesis
|
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Thyroid hormone signaling pathway
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Oxytocin signaling pathway
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Glucagon signaling pathway
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Regulation of lipolysis in adipocytes
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Renin secretion
|
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Endocrine and other factor-regulated calcium reabsorption
|
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Vasopressin-regulated water reabsorption
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Salivary secretion
|
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Gastric acid secretion
|
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Bile secretion
|
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Parkinson's disease
|
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Prion diseases
|
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Cocaine addiction
|
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Amphetamine addiction
|
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Morphine addiction
|
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Alcoholism
|
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Vibrio cholerae infection
|
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Amoebiasis
|
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Epstein-Barr virus infection
|
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Viral carcinogenesis
|
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Dilated cardiomyopathy
|
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Sphingolipid signaling pathway
|
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Axon guidance
|
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Osteoclast differentiation
|
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Adherens junction
|
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Natural killer cell mediated cytotoxicity
|
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T cell receptor signaling pathway
|
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Fc epsilon RI signaling pathway
|
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Pathogenic Escherichia coli infection
|
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Measles
|
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Viral myocarditis
|
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ErbB signaling pathway
|
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cGMP-PKG signaling pathway
|
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HIF-1 signaling pathway
|
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FoxO signaling pathway
|
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mTOR signaling pathway
|
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Dorso-ventral axis formation
|
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TGF-beta signaling pathway
|
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Toll-like receptor signaling pathway
|
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NOD-like receptor signaling pathway
|
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B cell receptor signaling pathway
|
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Fc gamma R-mediated phagocytosis
|
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TNF signaling pathway
|
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Neurotrophin signaling pathway
|
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Long-term depression
|
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Prolactin signaling pathway
|
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Type II diabetes mellitus
|
|
Aldosterone-regulated sodium reabsorption
|
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Alzheimer's disease
|
|
Shigellosis
|
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Salmonella infection
|
|
Pertussis
|
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Leishmaniasis
|
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Chagas disease (American trypanosomiasis)
|
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Toxoplasmosis
|
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Tuberculosis
|
|
Hepatitis C
|
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Hepatitis B
|
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Influenza A
|
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Colorectal cancer
|
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Renal cell carcinoma
|
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Pancreatic cancer
|
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Endometrial cancer
|
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Thyroid cancer
|
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Chronic myeloid leukemia
|
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Acute myeloid leukemia
|
|
Non-small cell lung cancer
|
|
Epithelial cell signaling in Helicobacter pylori infection
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
|
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IL1 Signaling Pathway
|
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IL2 Signaling Pathway
|
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TSH Signaling Pathway
|
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TCR Signaling Pathway
|
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IL4 Signaling Pathway
|
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EGFR1 Signaling Pathway
|
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Panther Pathway
|
FGF signaling pathway
|
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Angiogenesis
|
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PDGF signaling pathway
|
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VEGF signaling pathway
|
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Endothelin signaling pathway
|
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
|
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Inflammation mediated by chemokine and cytokine signaling pathway
|
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Metabotropic glutamate receptor group III pathway
|
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Metabotropic glutamate receptor group II pathway
|
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Metabotropic glutamate receptor group I pathway
|
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Muscarinic acetylcholine receptor 2 and 4 signaling pathway
|
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5HT1 type receptor mediated signaling pathway
|
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Beta1 adrenergic receptor signaling pathway
|
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Beta2 adrenergic receptor signaling pathway
|
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Histamine H2 receptor mediated signaling pathway
|
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GABA-B receptor II signaling
|
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Dopamine receptor mediated signaling pathway
|
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Enkephalin release
|
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Nicotine pharmacodynamics pathway
|
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CCKR signaling map ST
|
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Axon guidance mediated by semaphorins
|
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Cadherin signaling pathway
|
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Integrin signalling pathway
|
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Parkinson disease
|
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Hedgehog signaling pathway
|
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Transcription regulation by bZIP transcription factor
|
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Alzheimer disease-amyloid secretase pathway
|
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Apoptosis signaling pathway
|
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B cell activation
|
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EGF receptor signaling pathway
|
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Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
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Interferon-gamma signaling pathway
|
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Interleukin signaling pathway
|
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TGF-beta signaling pathway
|
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T cell activation
|
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Ras Pathway
|
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Angiotensin II-stimulated signaling through G proteins and beta-arrestin
|
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Pathwhiz Pathway
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Muscle/Heart Contraction
|
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Fc Epsilon Receptor I Signaling in Mast Cells
|
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
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Insulin Signalling
|
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Pathway Interaction Database
|
ATF-2 transcription factor network
|
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PDGFR-alpha signaling pathway
|
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PDGF receptor signaling network
|
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FGF signaling pathway
|
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HIF-2-alpha transcription factor network
|
|
Beta3 integrin cell surface interactions
|
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Signaling events mediated by TCPTP
|
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SHP2 signaling
|
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S1P1 pathway
|
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VEGF and VEGFR signaling network
|
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Integrins in angiogenesis
|
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Signaling events mediated by VEGFR1 and VEGFR2
|
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Notch-mediated HES/HEY network
|
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GMCSF-mediated signaling events
|
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LPA4-mediated signaling events
|
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Signaling events regulated by Ret tyrosine kinase
|
|
LKB1 signaling events
|
|
Thromboxane A2 receptor signaling
|
|
Signaling events mediated by HDAC Class I
|
|
Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
|
Glucocorticoid receptor regulatory network
|
|
ErbB2/ErbB3 signaling events
|
|
IL3-mediated signaling events
|
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Syndecan-1-mediated signaling events
|
|
Retinoic acid receptors-mediated signaling
|
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Hedgehog signaling events mediated by Gli proteins
|
|
VEGFR1 specific signals
|
|
Calcium signaling in the CD4+ TCR pathway
|
|
Syndecan-2-mediated signaling events
|
|
Aurora A signaling
|
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Class I PI3K signaling events mediated by Akt
|
|
Alpha4 beta1 integrin signaling events
|
|
Fc-epsilon receptor I signaling in mast cells
|
|
ErbB4 signaling events
|
|
Glypican 1 network
|
|
TCR signaling in naï
|
|
|
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Signaling events mediated by PTP1B
|
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Ephrin A reverse signaling
|
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Reelin signaling pathway
|
|
Regulation of p38-alpha and p38-beta
|
|
TCR signaling in naï
|
|
|
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Angiopoietin receptor Tie2-mediated signaling
|
|
Netrin-mediated signaling events
|
|
IL2-mediated signaling events
|
|
CXCR4-mediated signaling events
|
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Class I PI3K signaling events
|
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Posttranslational regulation of adherens junction stability and dissassembly
|
|
amb2 Integrin signaling
|
|
EPHA forward signaling
|
|
E-cadherin signaling in keratinocytes
|
|
PDGFR-beta signaling pathway
|
|
Nephrin/Neph1 signaling in the kidney podocyte
|
|
Syndecan-3-mediated signaling events
|
|
Ephrin B reverse signaling
|
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Alpha-synuclein signaling
|
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Signaling events mediated by focal adhesion kinase
|
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S1P3 pathway
|
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Nectin adhesion pathway
|
|
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
|
|
Validated targets of C-MYC transcriptional repression
|
|
Syndecan-4-mediated signaling events
|
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N-cadherin signaling events
|
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Endothelins
|
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BCR signaling pathway
|
|
Signaling events mediated by PRL
|
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
|
EPHB forward signaling
|
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Osteopontin-mediated events
|
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S1P4 pathway
|
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Presenilin action in Notch and Wnt signaling
|
|
TRAIL signaling pathway
|
|
CDC42 signaling events
|
|
Regulation of Telomerase
|
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Arf6 downstream pathway
|
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mTOR signaling pathway
|
|
Class IB PI3K non-lipid kinase events
|
|
EGF receptor (ErbB1) signaling pathway
|
|
Ras signaling in the CD4+ TCR pathway
|
|
Ceramide signaling pathway
|
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IFN-gamma pathway
|
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ErbB1 downstream signaling
|
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BMP receptor signaling
|
|
ALK1 signaling events
|
|
Neurotrophic factor-mediated Trk receptor signaling
|
|
Nongenotropic Androgen signaling
|
|
CXCR3-mediated signaling events
|
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Regulation of cytoplasmic and nuclear SMAD2/3 signaling
|
|
Cellular roles of Anthrax toxin
|
|
S1P2 pathway
|
|
Trk receptor signaling mediated by the MAPK pathway
|
|
Downstream signaling in naï
|
|
VEGFR3 signaling in lymphatic endothelium
|
|
LPA receptor mediated events
|
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Arf6 signaling events
|
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EGFR-dependent Endothelin signaling events
|
|
Direct p53 effectors
|
|
ErbB receptor signaling network
|
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Internalization of ErbB1
|
|
Stabilization and expansion of the E-cadherin adherens junction
|
|
a6b1 and a6b4 Integrin signaling
|
|
Reactome
|
FGFR3 mutant receptor activation
|
|
PIP3 activates AKT signaling
|
|
Constitutive Signaling by Aberrant PI3K in Cancer
|
|
RAF/MAP kinase cascade
|
|
Activated point mutants of FGFR2
|
|
Neurophilin interactions with VEGF and VEGFR
|
|
VEGF binds to VEGFR leading to receptor dimerization
|
|
Integrin cell surface interactions
|
|
EPHA-mediated growth cone collapse
|
|
VEGFA-VEGFR2 Pathway
|
|
VEGFR2 mediated cell proliferation
|
|
PI3K Cascade
|
|
FGFR4 ligand binding and activation
|
|
Phospholipase C-mediated cascade
|
|
FRS-mediated FGFR4 signaling
|
|
SHC-mediated cascade:FGFR4
|
|
PI-3K cascade:FGFR4
|
|
Negative regulation of FGFR4 signaling
|
|
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
|
|
PKA activation
|
|
PKA activation in glucagon signalling
|
|
DARPP-32 events
|
|
Regulation of PLK1 Activity at G2/M Transition
|
|
Loss of Nlp from mitotic centrosomes
|
|
Recruitment of mitotic centrosome proteins and complexes
|
|
Loss of proteins required for interphase microtubule organization?from the centrosome
|
|
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
|
|
Regulation of insulin secretion
|
|
Vasopressin regulates renal water homeostasis via Aquaporins
|
|
Interleukin-3, 5 and GM-CSF signaling
|
|
Degradation of GLI1 by the proteasome
|
|
Degradation of GLI2 by the proteasome
|
|
Hedgehog 'off' state
|
|
Anchoring of the basal body to the plasma membrane
|
|
CD209 (DC-SIGN) signaling
|
|
MAPK6/MAPK4 signaling
|
|
Gluconeogenesis
|
|
Factors involved in megakaryocyte development and platelet production
|
|
GPVI-mediated activation cascade
|
|
Regulation of KIT signaling
|
|
Cell surface interactions at the vascular wall
|
|
FCGR activation
|
|
PECAM1 interactions
|
|
DAP12 signaling
|
|
EPH-Ephrin signaling
|
|
Role of LAT2/NTAL/LAB on calcium mobilization
|
|
Nephrin interactions
|
|
NCAM signaling for neurite out-growth
|
|
CD28 co-stimulation
|
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CD28 dependent PI3K/Akt signaling
|
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CD28 dependent Vav1 pathway
|
|
CTLA4 inhibitory signaling
|
|
EPHB-mediated forward signaling
|
|
EPH-ephrin mediated repulsion of cells
|
|
CRMPs in Sema3A signaling
|
|
DCC mediated attractive signaling
|
|
Netrin mediated repulsion signals
|
|
Dectin-2 family
|
|
Platelet Adhesion to exposed collagen
|
|
Regulation of signaling by CBL
|
|
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
|
|
RAF-independent MAPK1/3 activation
|
|
MAPK1 (ERK2) activation
|
|
Golgi Cisternae Pericentriolar Stack Reorganization
|
|
ERK/MAPK targets
|
|
Regulation of actin dynamics for phagocytic cup formation
|
|
Oxidative Stress Induced Senescence
|
|
Senescence-Associated Secretory Phenotype (SASP)
|
|
Oncogene Induced Senescence
|
|
FCERI mediated MAPK activation
|
|
Regulation of HSF1-mediated heat shock response
|
|
Recycling pathway of L1
|
|
CREB phosphorylation through the activation of Ras
|
|
Activation of the AP-1 family of transcription factors
|
|
Thrombin signalling through proteinase activated receptors (PARs)
|
|
Negative regulation of FGFR1 signaling
|
|
Negative regulation of FGFR2 signaling
|
|
Negative regulation of FGFR3 signaling
|
|
RHO GTPases Activate WASPs and WAVEs
|
|
MAP2K and MAPK activation
|
|
Negative feedback regulation of MAPK pathway
|
|
Negative regulation of MAPK pathway
|
|
Signal attenuation
|
|
Advanced glycosylation endproduct receptor signaling
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
Growth hormone receptor signaling
|
|
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
|
|
SHC1 events in ERBB2 signaling
|
|
PLCG1 events in ERBB2 signaling
|
|
GRB2 events in EGFR signaling
|
|
GAB1 signalosome
|
|
SHC1 events in EGFR signaling
|
|
EGFR downregulation
|
|
GRB2 events in ERBB2 signaling
|
|
PI3K events in ERBB2 signaling
|
|
EGFR Transactivation by Gastrin
|
|
Constitutive Signaling by EGFRvIII
|
|
WikiPathways
|
Regulation of Actin Cytoskeleton
|
|
Endochondral Ossification
|
|
Bladder Cancer
|
|
Neural Crest Differentiation
|
|
Signaling by FGFR
|
|
Osteoblast Signaling
|
|
Focal Adhesion
|
|
Hair Follicle Development: Organogenesis (Part 2 of 3)
|
|
PIP3 activates AKT signaling
|
|
Cardiac Progenitor Differentiation
|
|
Integrated Pancreatic Cancer Pathway
|
|
Allograft Rejection
|
|
Signaling Pathways in Glioblastoma
|
|
Signaling by PDGF
|
|
Angiogenesis
|
|
Ectoderm Differentiation
|
|
Hair Follicle Development: Induction (Part 1 of 3)
|
|
Cardiac Hypertrophic Response
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Nifedipine Activity
|
|
Signaling by VEGF
|
|
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
|
SIDS Susceptibility Pathways
|
|
Hypothetical Network for Drug Addiction
|
|
Calcium Regulation in the Cardiac Cell
|
|
MAPK Signaling Pathway
|
|
G Protein Signaling Pathways
|
|
Myometrial Relaxation and Contraction Pathways
|
|
IL-3 Signaling Pathway
|
|
Mesodermal Commitment Pathway
|
|
Human Complement System
|
|
DAG and IP3 signaling
|
|
Regulation of Water Balance by Renal Aquaporins
|
|
Dopamine metabolism
|
|
Regulation of Microtubule Cytoskeleton
|
|
FSH signaling pathway
|
|
miRs in Muscle Cell Differentiation
|
|
SREBP signalling
|
|
Opioid Signalling
|
|
Mitotic G2-G2/M phases
|
|
Integration of energy metabolism
|
|
Factors involved in megakaryocyte development and platelet production
|
|
Nicotine Activity on Dopaminergic Neurons
|
|
TCR Signaling Pathway
|
|
Interferon type I signaling pathways
|
|
IL-2 Signaling Pathway
|
|
Kit receptor signaling pathway
|
|
Fc epsilon receptor (FCERI) signaling
|
|
Signaling by the B Cell Receptor (BCR)
|
|
Signaling by SCF-KIT
|
|
DAP12 interactions
|
|
Host Interactions of HIV factors
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
|
Primary Focal Segmental Glomerulosclerosis FSGS
|
|
BDNF signaling pathway
|
|
Interleukin-11 Signaling Pathway
|
|
B Cell Receptor Signaling Pathway
|
|
Pathogenic Escherichia coli infection
|
|
TSLP Signaling Pathway
|
|
IL-7 Signaling Pathway
|
|
Leptin signaling pathway
|
|
Semaphorin interactions
|
|
Platelet Adhesion to exposed collagen
|
|
Netrin-1 signaling
|
|
Nephrin interactions
|
|
NCAM signaling for neurite out-growth
|
|
Integrin-mediated Cell Adhesion
|
|
GPVI-mediated activation cascade
|
|
Costimulation by the CD28 family
|
|
Cell surface interactions at the vascular wall
|
|
PDGF Pathway
|
|
Toll-like receptor signaling pathway
|
|
Serotonin Receptor 4/6/7 and NR3C Signaling
|
|
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
|
Serotonin HTR1 Group and FOS Pathway
|
|
Vitamin A and Carotenoid Metabolism
|
|
DNA Damage Response (only ATM dependent)
|
|
ErbB Signaling Pathway
|
|
Senescence and Autophagy in Cancer
|
|
EPO Receptor Signaling
|
|
Insulin Signaling
|
|
EGF/EGFR Signaling Pathway
|
|
MAPK Cascade
|
|
IL-4 Signaling Pathway
|
|
TGF beta Signaling Pathway
|
|
IL-6 signaling pathway
|
|
Signaling of Hepatocyte Growth Factor Receptor
|
|
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
|
|
Apoptosis-related network due to altered Notch3 in ovarian cancer
|
|
MAP kinase activation in TLR cascade
|
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
RAF/MAP kinase cascade
|
|
Nanoparticle-mediated activation of receptor signaling
|
|
Structural Pathway of Interleukin 1 (IL-1)
|
|
Genes and (Common) Pathways Underlying Drug Addiction
|
|
EBV LMP1 signaling
|
|
Signal Transduction of S1P Receptor
|
|
Aryl Hydrocarbon Receptor
|
|
Alpha 6 Beta 4 signaling pathway
|
|
Spinal Cord Injury
|
|
Oncostatin M Signaling Pathway
|
|
Corticotropin-releasing hormone
|
|
AGE/RAGE pathway
|
|
TNF alpha Signaling Pathway
|
|
Prostate Cancer
|
|
IL-9 Signaling Pathway
|
|
Endothelin Pathways
|
|
IL17 signaling pathway
|
|
Alzheimers Disease
|
|
TWEAK Signaling Pathway
|
|
RANKL/RANK Signaling Pathway
|
|
Integrated Breast Cancer Pathway
|
|
IL-1 signaling pathway
|
|
Thrombin signalling through proteinase activated receptors (PARs)
|
|
L1CAM interactions
|
|
Advanced glycosylation endproduct receptor signaling
|
|
Heart Development
|
|
Type II diabetes mellitus
|
|
Physiological and Pathological Hypertrophy of the Heart
|
|
Regulation of toll-like receptor signaling pathway
|
|
Osteopontin Signaling
|
|
IL-5 Signaling Pathway
|
|
Aryl Hydrocarbon Receptor Pathway
|
|
Extracellular vesicle-mediated signaling in recipient cells
|
|
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
|
|
Signaling by ERBB4
|
|
Signaling by ERBB2
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
Gastric cancer network 2
|
|
Arylhydrocarbon receptor (AhR) signaling pathway
|
|
miR-targeted genes in muscle cell - TarBase
|
|
miR-targeted genes in lymphocytes - TarBase
|
|
miR-targeted genes in epithelium - TarBase
|
|
Signaling by EGFR
|
