Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09WYY
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| Former ID |
DNC000052
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| Drug Name |
2'-deoxythymidine triphosphate
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| Synonyms |
Thymidine-5'-triphosphate; dTTP; thymidine 5'-triphosphate; Deoxy-TTP; Deoxythymidine 5'-triphosphate; 2'-Deoxythymidine triphosphate; 5'-TTP; THYMIDINE-5'-TRIPHOSPHATE; thymidine 5'-(tetrahydrogen triphosphate); TTP (nucleotide); thymidine triphosphate; pppdT; TTP; UNII-QOP4K539MU; 5-Methyl-dUTP; dThd5'PPP; CHEBI:18077; EINECS 206-669-7; QOP4K539MU; CHEMBL363559; 2'-Deoxythymidine 5'-triphosphate; 18423-43-3; [hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate; DEOXYTHYMIDINE_TRIPHOSPHATE; Thymidine-5'-Triphosphate
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2], [3] | |
| Structure |
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Download2D MOL |
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| Formula |
C10H17N2O14P3
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| Canonical SMILES |
CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O
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| InChI |
1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1
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| InChIKey |
NHVNXKFIZYSCEB-XLPZGREQSA-N
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| CAS Number |
CAS 365-08-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3743, 614194, 820340, 822735, 826788, 827223, 828532, 829465, 836046, 841580, 854540, 7890908, 8010468, 8023754, 8025706, 8143900, 10322519, 10322526, 14883523, 14932553, 17422853, 22394781, 24277245, 24423798, 24771318, 26711327, 26716525, 26717860, 26719008, 43121823, 46392097, 46392773, 46393735, 48409737, 49693289, 50054711, 50139633, 57288126, 57288129, 57315215, 57654824, 57654936, 74374224, 80950629, 85261548, 87457645, 87544183, 87544338, 87544341, 96021852
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| ChEBI ID |
CHEBI:18077
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Herpes simplex virus DNA polymerase UL30 (HSV UL30) | Target Info | Inhibitor | [2] |
| Human immunodeficiency virus Reverse transcriptase (HIV RT) | Target Info | Inhibitor | [3] | |
| Mycobacterium Thymidine monophosphate kinase (MycB tmk) | Target Info | Inhibitor | [4] | |
| Thymidine kinase 1 (TK1) | Target Info | Inhibitor | [4] | |
| KEGG Pathway | Pyrimidine metabolism | |||
| Metabolic pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5505). | |||
| REF 2 | Inhibition of human hepatitis B virus DNA polymerase and duck hepatitis B virus DNA polymerase by triphosphates of thymidine analogs and pharmacokinetic properties of the corresponding nucleosides. JMed Virol. 1988 Dec;26(4):353-62. | |||
| REF 3 | Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcript... J Med Chem. 2005 Apr 7;48(7):2695-700. | |||
| REF 4 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
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