Drug Information
Drug General Information | Top | |||
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Drug ID |
D09FGX
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Former ID |
DNC009018
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Drug Name |
Elacridar
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Synonyms |
Elacridar hydrochloride; 143851-98-3; Elacridar HCl; Elacridar (hydrochloride); gf 120918a; UNII-NX2BHH1A5B; NX2BHH1A5B; Elacridar hydrochloride [USAN]; GF-120918A; Elacridar hydrochloride (USAN); GF 120918; AC1Q3EOG; AC1L55DX; C34H34ClN3O5; SCHEMBL15847793; CHEMBL2074730; AOB5938; MolPort-023-332-877; BCP14056; 7066AA; AKOS016005297; CS-1113; ACN-041487; 4CA-0489; HY-50880; AC-30266; FT-0696337; W-5457; D03968; N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydro
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Drug Type |
Small molecular drug
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Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Discontinued in Phase 1 | [1] | |
Structure |
Download2D MOL |
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Formula |
C34H33N3O5
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Canonical SMILES |
COC1=CC=CC2=C1NC3=C(C2=O)C=CC=C3C(=O)NC4=CC=C(C=C4)CCN5CCC6=CC(=C(C=C6C5)OC)OC
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InChI |
1S/C34H33N3O5/c1-40-28-9-5-7-26-32(28)36-31-25(33(26)38)6-4-8-27(31)34(39)35-24-12-10-21(11-13-24)14-16-37-17-15-22-18-29(41-2)30(42-3)19-23(22)20-37/h4-13,18-19H,14-17,20H2,1-3H3,(H,35,39)(H,36,38)
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InChIKey |
OSFCMRGOZNQUSW-UHFFFAOYSA-N
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CAS Number |
CAS 143664-11-3
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Multidrug resistance protein 1 (ABCB1) | Target Info | Inhibitor | [2] |
KEGG Pathway | ABC transporters | |||
Bile secretion | ||||
MicroRNAs in cancer | ||||
NetPath Pathway | IL2 Signaling Pathway | |||
TCR Signaling Pathway | ||||
Pathway Interaction Database | HIF-1-alpha transcription factor network | |||
Reactome | ABC-family proteins mediated transport | |||
WikiPathways | Nuclear Receptors in Lipid Metabolism and Toxicity | |||
Abacavir transport and metabolism | ||||
Multi Drug Resistance Protein 1 (Glycoprotein 1) Regulation | ||||
Integrated Pancreatic Cancer Pathway | ||||
Allograft Rejection | ||||
Drug Induction of Bile Acid Pathway | ||||
Codeine and Morphine Metabolism |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002537) | |||
REF 2 | 2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties. J Med Chem. 2008 Dec 11;51(23):7602-13. |
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