Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09AXB
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| Former ID |
DNC008063
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| Drug Name |
SB-201076
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| Synonyms |
CHEMBL324097; 154566-05-9; SB-201076; SCHEMBL2622309; ZINC13781097; BDBM50066692; KB-145947; (S)-2-((S)-8-(2,4-dichlorophenyl)-2-hydroxyoctyl)-2-hydroxysuccinic acid; (S)-2-[(S)-8-(2,4-Dichloro-phenyl)-2-hydroxy-octyl]-2-hydroxy-succinic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C18H24Cl2O6
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| Canonical SMILES |
C1=CC(=C(C=C1Cl)Cl)CCCCCCC(CC(CC(=O)O)(C(=O)O)O)O
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| InChI |
1S/C18H24Cl2O6/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14(21)10-18(26,17(24)25)11-16(22)23/h7-9,14,21,26H,1-6,10-11H2,(H,22,23)(H,24,25)/t14-,18+/m1/s1
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| InChIKey |
NPZOIISFQXTCQN-KDOFPFPSSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | ATP-citrate synthase (ACLY) | Target Info | Inhibitor | [1] |
| BioCyc | Acetyl-CoA biosynthesis from citrate | |||
| KEGG Pathway | Citrate cycle (TCA cycle) | |||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Pathwhiz Pathway | Transfer of Acetyl Groups into Mitochondria | |||
| Reactome | ChREBP activates metabolic gene expression | |||
| Fatty Acyl-CoA Biosynthesis | ||||
| WikiPathways | Fatty Acid Biosynthesis | |||
| TCA Cycle and PDHc | ||||
| Butyrate-induced histone acetylation | ||||
| SREBP signalling | ||||
| Integration of energy metabolism | ||||
| Fatty acid, triacylglycerol, and ketone body metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The biology and chemistry of hyperlipidemia. Bioorg Med Chem. 2007 Jul 15;15(14):4674-99. | |||
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