Drug Information
Drug General Information | Top | |||
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Drug ID |
D07XHO
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Former ID |
DNC000983
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Drug Name |
Nafamostat
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Synonyms |
FUT-175; Nafamostat [INN]; Nafamostatum [Latin]; UNII-Y25LQ0H97D; Nafamstat; Nafamstat Mesilate; 6-Amidino2-naphthyl 4-guanidinobenzoate; Y25LQ0H97D; CHEMBL273264; C19H17N5O2; Nafamostat (INN); p-Guanidinobenzoic acid ester with 6-hydroxy-2-naphthamidine; Nafamostatum
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Drug Type |
Small molecular drug
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Indication | Pancreatitis [ICD-11: DC31-DC34] | Approved | [1], [2] | |
Sepsis [ICD-11: 1G40-1G41; ICD-9: 995.91] | Discontinued in Phase 2 | [3] | ||
Structure |
Download2D MOL |
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Formula |
C19H17N5O2
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Canonical SMILES |
C1=CC(=CC=C1C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(=N)N)N=C(N)N
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InChI |
1S/C19H17N5O2/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23/h1-10H,(H3,20,21)(H4,22,23,24)
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InChIKey |
MQQNFDZXWVTQEH-UHFFFAOYSA-N
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CAS Number |
CAS 81525-10-2
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PubChem Compound ID | ||||
PubChem Substance ID |
5096568, 14778337, 26754619, 29216079, 29223510, 47365353, 50065252, 50110097, 50334592, 57322261, 89650190, 91615064, 96024928, 103170416, 103824925, 103958902, 104306334, 117575270, 124892269, 125823849, 128633897, 129980079, 131327125, 134222539, 134339097, 134340258, 135062511, 137051650, 137120697, 138817266, 142058227, 164230816, 164813659, 178101079, 179151201, 184545971, 186009066, 198971060, 210279319, 210281642, 212296217, 223365680, 223401665, 226503299, 251916771, 251918010, 252480071
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ChEBI ID |
CHEBI:135466
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References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4262). | |||
REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 3 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006437) | |||
REF 4 | Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients. Int J Oncol. 2009 Jul;35(1):115-20. | |||
REF 5 | Clinical pipeline report, company report or official report of AstraZeneca (2009). |
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