Drug General Information
Drug ID
D07ALX
Drug Name
Sirolimus
Synonyms
Rapammune; Sirolimus; Rapamycin; I2190A; 53123-88-9; (-)-Rapamycin; Wy 090217; SIIA 9268A; Rapamune; I-2190A; AY-22989; RAPA; NSC 226080; I 2190A; AY 22989; Rapamycin (Sirolimus); WY-090217; Antibiotic AY 22989; UNII-W36ZG6FT64; SILA 9268A; CHEBI:9168; CCRIS 9024; W36ZG6FT64; HSDB 7284; C51H79NO13; DE-109; NCGC00021305-05; DSSTox_CID_3582; DSSTox_RID_77091; DSSTox_GSID_23582; Supralimus; Sirolimus
Drug Type
Small molecular drug
Indication Lymphangioleiomyomatosis [ICD-11: CB07] Approved [1]
Coronavirus Disease 2019 (COVID-19) [ICD-11: 1D6Y] Phase 2 [2]
Therapeutic Class
Antiviral Agents
Structure
Download
2D MOL

Formula
C51H79NO13
InChI
1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChIKey
QFJCIRLUMZQUOT-HPLJOQBZSA-N
CAS Number
CAS 53123-88-9
PubChem Compound ID
Target and Pathway
Target(s) HUMAN mammalian target of rapamycin (mTOR) Target Info Inhibitor [3]
References
REF 1 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 201578.
REF 2 ClinicalTrials.gov (NCT04341675) Sirolimus Treatment in Hospitalized Patients With COVID-19 Pneumonia. U.S. National Institutes of Health.
REF 3 Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2. Cell Discov. 2020 Mar 16;6:14.

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