Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06WRJ
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| Former ID |
DIB015104
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| Drug Name |
Icotinib hydrochloride
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| Synonyms |
Conmana; Conmanna; Icotinib; BPI-2009-H
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| Drug Type |
Small molecular drug
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| Indication | Non-small-cell lung cancer [ICD-11: 2C25.Y] | Registered | [1], [2], [3] | |
| Company |
Beta Pharma Inc
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| Structure |
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Download2D MOL
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| Formula |
C22H22ClN3O4
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| Canonical SMILES |
C#CC1=CC(=CC=C1)NC2=NC=NC3=CC4=C(C=C32)OCCOCCOCCO4.Cl
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| InChI |
1S/C22H21N3O4.ClH/c1-2-16-4-3-5-17(12-16)25-22-18-13-20-21(14-19(18)23-15-24-22)29-11-9-27-7-6-26-8-10-28-20;/h1,3-5,12-15H,6-11H2,(H,23,24,25);1H
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| InChIKey |
PNNGXMJMUUJHAV-UHFFFAOYSA-N
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| CAS Number |
CAS 1204313-51-8
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7641). | |||
| REF 2 | Clinical pipeline report, company report or official report of Beta Pharma. | |||
| REF 3 | ClinicalTrials.gov (NCT02404675) High Dose Icotinib in Advanced Non-small Cell Lung Cancer Patients With EGFR 21 Exon Positive. U.S. National Institutes of Health. | |||
| REF 4 | Phase I study of icotinib hydrochloride (BPI-2009H), an oral EGFR tyrosine kinase inhibitor, in patients with advanced NSCLC and other solid tumors. Lung Cancer. 2011 Aug;73(2):195-202. | |||
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