Drug Information

Drug General Information

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Drug ID

D06NMZ

Former ID

DNC001052

Drug Name

NVP-ADW742

Synonyms

NVP-ADW742; 475488-23-4; ADW-742; 475489-15-7; UNII-MXS2N5862L; ADW742; MXS2N5862L; CHEMBL399021; 5-(3-(Benzyloxy)phenyl)-7-((1r,3r)-3-(pyrrolidin-1-ylmethyl)-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 5-(3-(Benzyloxy)phenyl)-7-(cis-3-(pyrrolidin-1-ylmethyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; C28H31N5O; 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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Drug Type

Small molecular drug

Indication

Multiple myeloma [ICD-11: 2A83; ICD-10: C90.0]

Investigative

[1]

Company

Novartis

Structure

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2D MOL

3D MOL

Formula

C28H31N5O

Canonical SMILES

C1CCN(C1)CC2CC(C2)N3C=C(C4=C(N=CN=C43)N)C5=CC(=CC=C5)OCC6=CC=CC=C6

InChI

1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(15-22)34-18-20-7-2-1-3-8-20)17-33(28(26)31-19-30-27)23-13-21(14-23)16-32-11-4-5-12-32/h1-3,6-10,15,17,19,21,23H,4-5,11-14,16,18H2,(H2,29,30,31)

InChIKey

LSFLAQVDISHMNB-UHFFFAOYSA-N

CAS Number

CAS 475488-23-4

PubChem Compound ID

9825149

PubChem Substance ID

14784297, 15167856, 24127797, 44923287, 53837761, 74517124, 103550967, 103904996, 104092611, 117695996, 124756989, 125163794, 131480752, 134340305, 136367288, 137778791, 139380001, 140885742, 141546423, 144116293, 152258154, 160646991, 162011873, 162037425, 162202652, 163907941, 164339439, 174006571, 174529497, 180190868, 186014832, 202553532, 223397881, 226472395, 228142956, 228142958, 241377378, 242526284, 242800901, 245990226, 248492712, 251963182, 252110001, 252158717, 252215927, 252437621, 252823856

Target and Pathway

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Target(s)

Insulin-like growth factor I receptor (IGF1R)

Target Info

Inhibitor

[1]

KEGG Pathway

Ras signaling pathway

Rap1 signaling pathway

HIF-1 signaling pathway

FoxO signaling pathway