Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05VLS
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| Former ID |
DAP001338
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| Drug Name |
Rofecoxib
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| Synonyms |
Ceoxx; Refecoxib; Vioxx; Cahill May Roberts brand of rofecoxib; MSD brand of rofecoxib; Merck Frosst brandof rofecoxib; Merck brand of rofecoxib; Vioxx Dolor; MK 0966; MK 0996; MK 966; MK0966; Ceeoxx (TN); Ceoxx (TN); KS-1107; MK-0966; MK-966; Merck Sharp & Dhome brand of rofecoxib; Vioxx (TN); Vioxx (trademark); Rofecoxib (JAN/USAN/INN); 3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one; 3-Phenyl-4-(4-(methylsulfonyl)phenyl))-2(5H)-furanone; 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone; 4-(4-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone; 4-(4-methylsulfonylphenyl)-3-phenyl-5H-furan-2-one; 4-(p-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone; 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone; 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
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| Drug Type |
Small molecular drug
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| Indication | Osteoarthritis [ICD-11: FA00-FA05; ICD-9: 715] | Approved | [1], [2] | |
| Therapeutic Class |
Antiinflammatory Agents
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| Company |
Merck & Co
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| Structure |
 |
Download2D MOL |
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| Formula |
C17H14O4S
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| Canonical SMILES |
CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3
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| InChI |
1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3
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| InChIKey |
RZJQGNCSTQAWON-UHFFFAOYSA-N
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| CAS Number |
CAS 162011-90-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9792, 535364, 5146347, 7847634, 7980536, 8146414, 8153131, 11341940, 11362123, 11362973, 11364757, 11365535, 11367319, 11368097, 11369881, 11372304, 11372922, 11374381, 11375481, 11376259, 11378046, 11445527, 11484228, 11487525, 11488262, 11490968, 11492446, 11493933, 11528653, 12014954, 14752370, 25819946, 26612684, 26680170, 26719838, 26748942, 26748943, 29224158, 46386634, 46504787, 47365310, 47810857, 48334605, 48416526, 49665949, 49666006, 49681737, 49846184, 50107491, 50107492
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| ChEBI ID |
CHEBI:8887
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| ADReCS Drug ID | BADD_D01961 | |||
| SuperDrug ATC ID |
M01AH02
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| SuperDrug CAS ID |
cas=162011907
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2893). | |||
| REF 2 | New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202. | |||
| REF 3 | Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19. | |||
| REF 4 | Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51. | |||
| REF 5 | Aromatase inhibitors--theoretical concept and present experiences in the treatment of endometriosis. Zentralbl Gynakol. 2003 Jul-Aug;125(7-8):247-51. | |||
| REF 6 | The effect of the selective cyclooxygenase-2 inhibitor rofecoxib on human colorectal cancer liver metastases. Gastroenterology. 2003 Sep;125(3):716-29. | |||
| REF 7 | Clinical experience with cyclooxygenase-2 inhibitors. Rheumatology (Oxford). 2002 Apr;41 Supp 1:16-22; discussion 35-42. | |||
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