Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05PZB
|
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| Former ID |
DCL000059
|
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| Drug Name |
AT9283
|
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| Drug Type |
Small molecular drug
|
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 3 | [1], [2] | |
| Therapeutic Class |
Anticancer Agents
|
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| Company |
Astex Therape.
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C19H23N7O2
|
|||
| Canonical SMILES |
C1CC1NC(=O)NC2=C(NN=C2)C3=NC4=C(N3)C=C(C=C4)CN5CCOCC5
|
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| InChI |
1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13H,2-3,5-8,11H2,(H,20,25)(H,22,23)(H2,21,24,27)
|
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| InChIKey |
LOLPPWBBNUVNQZ-UHFFFAOYSA-N
|
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| CAS Number |
CAS 896466-04-9
|
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:125514
|
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7949). | |||
| REF 2 | A phase I trial of AT9283 (a selective inhibitor of aurora kinases) in children and adolescents with solid tumors: a Cancer Research UK study. Clin Cancer Res. 2015 Jan 15;21(2):267-73. | |||
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