Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05OHY
|
|||
| Drug Name |
CAR-T cells targeting EphA2
|
|||
| Drug Type |
CAR T Cell Therapy
|
|||
| Indication | Malignant glioma [ICD-11: 2A00.0; ICD-9: 191] | Phase 1/2 | [1] | |
| Company |
Fuda Cancer Hospital, Guangzhou
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Ephrin type-A receptor 2 (EPHA2) | Target Info | CAR-T-Cell-Therapy | [1] |
| KEGG Pathway | Ras signaling pathway | |||
| Rap1 signaling pathway | ||||
| PI3K-Akt signaling pathway | ||||
| Axon guidance | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Pathway Interaction Database | EphrinA-EPHA pathway | |||
| Arf6 signaling events | ||||
| Direct p53 effectors | ||||
| EPHA forward signaling | ||||
| Stabilization and expansion of the E-cadherin adherens junction | ||||
| EPHA2 forward signaling | ||||
| Reactome | EPH-Ephrin signaling | |||
| EPHA-mediated growth cone collapse | ||||
| EPH-ephrin mediated repulsion of cells | ||||
| WikiPathways | NRF2 pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT02575261) CAR-T Cell Immunotherapy for EphA2 Positive Malignant Glioma Patients | |||
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