Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04WFL
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| Former ID |
DAP000391
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| Drug Name |
Trastuzumab
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| Synonyms |
Herceptin; Herceptin (TN); Trastuzumab (INN); Trastuzumab (genetical recombination); Trastuzumab (genetical recombination) (JAN); Trastuzumab (ERBB2 mAb inhibitor)
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| Drug Type |
Antibody
|
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| Indication | Breast cancer [ICD-11: 2C60-2C65] | Approved | [1], [2], [3] | |
| Gastric adenocarcinoma [ICD-11: 2B72; ICD-9: 151] | Application submitted | [4] | ||
| HER2-positive breast cancer [ICD-11: 2C60-2C65] | Application submitted | [4] | ||
| Therapeutic Class |
Anticancer Agents
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| Company |
Roche; Genentech
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| PubChem Substance ID | ||||
| ADReCS Drug ID | BADD_D02264 | |||
| SuperDrug ATC ID |
L01XC03
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| SuperDrug CAS ID |
cas=180288691
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| Drug Resistance Mutation (DRM) | Top | |||
|---|---|---|---|---|
| DRM | DRM Info | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5082). | |||
| REF 2 | Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. | |||
| REF 3 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 4 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 5 | Her2/neu is not a commonly expressed therapeutic target in melanoma -- a large cohort tissue microarray study. Melanoma Res. 2004 Jun;14(3):207-10. | |||
| REF 6 | Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51. | |||
| REF 7 | Anti-ErbB-2 monoclonal antibodies and ErbB-2-directed vaccines. Cancer Immunol Immunother. 2002 Jan;50(11):569-87. | |||
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