Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04WDX
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| Former ID |
DNC001128
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| Drug Name |
PJ34
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| Synonyms |
PJ34; 344458-19-1; pj-34; N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE; CHEMBL372303; P34; 2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide; Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-; UYJZZVDLGDDTCL-UHFFFAOYSA-N; PJ34(free base); 1xk9; SCHEMBL422317; ZINC8960; AC1L1J45; BDBM27497; CTK1B7701; MolPort-035-395-737; Ibrutinib (PCI32765 pound(c); HMS3651B06; BCP07990; HY-13688A; 2662AH; AKOS030229047; SB19292; DB08348; CS-1463; NCGC00370866-10; DA-42692; BC600341
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| Drug Type |
Small molecular drug
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| Indication | Coronavirus infection [ICD-11: 1D92; ICD-10: B34.2] | Preclinical | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C17H17N3O2
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| Canonical SMILES |
CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32
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| InChI |
1S/C17H17N3O2/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22)
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| InChIKey |
UYJZZVDLGDDTCL-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5005827, 6435849, 6435929, 7889674, 8152987, 14898161, 29223939, 46393562, 47211625, 49649993, 57299206, 57304736, 80903002, 85756513, 99444819, 103468748, 104307634, 126408013, 134352305, 142463587, 162511565, 170474817, 177748919, 178483466, 185990451, 210274932, 210280569, 211786747, 223401601, 223519286, 223749822, 226087992, 226747694, 248281898, 252255698, 252473119
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Poly [ADP-ribose] polymerase 1 (PARP1) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Base excision repair | |||
| NF-kappa B signaling pathway | ||||
| Panther Pathway | FAS signaling pathway | |||
| Pathway Interaction Database | Integrin-linked kinase signaling | |||
| Caspase Cascade in Apoptosis | ||||
| Notch-mediated HES/HEY network | ||||
| Reactome | Dual Incision in GG-NER | |||
| WikiPathways | FAS pathway and Stress induction of HSP regulation | |||
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | ||||
| Nanoparticle triggered regulated necrosis | ||||
| Corticotropin-releasing hormone | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. | |||
| REF 2 | Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nat Med. 2001 Jan;7(1):108-13. | |||
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