Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D04TNI
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| Drug Name |
Nitroflurbiprofen
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| Synonyms |
Flurbinitroxybutylester; Flurbiprofen nitroxybutylester; HCT 1026; NO-flurbiprofen
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2], [3] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H20FNO5
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| Canonical SMILES |
CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)OCCCCO[N+](=O)[O-]
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| InChI |
1S/C19H20FNO5/c1-14(19(22)25-11-5-6-12-26-21(23)24)16-9-10-17(18(20)13-16)15-7-3-2-4-8-15/h2-4,7-10,13-14H,5-6,11-12H2,1H3
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| InChIKey |
DLWSRGHNJVLJAH-UHFFFAOYSA-N
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| CAS Number |
CAS 158836-71-6
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:77428
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | The cyclooxygenase inhibitor flurbiprofen reduces radiation-induced angiogenic growth factor secretion of squamous cell carcinoma cell lines. Ann N Y Acad Sci. 2004 Dec;1030:37-42. | |||
| REF 2 | Flurbiprofen, a cyclooxygenase inhibitor, protects mice from hepatic ischemia/reperfusion injury by inhibiting GSK-3 signaling and mitochondrial permeability transition.Mol Med.2012 Sep 25;18:1128-35. | |||
| REF 3 | Flurbiprofen: A Nonselective Cyclooxygenase (COX) Inhibitor for Treatment of Noninfectious, Non-necrotizing Anterior Scleritis.Ocul Immunol Inflamm.2016;24(1):35-42. | |||
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