Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03NPX
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| Former ID |
DNC006871
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| Drug Name |
PD-0173955
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| Synonyms |
PD-17395
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C21H16Cl2N4OS
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| Canonical SMILES |
CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)Cl)NC4=CC(=CC=C4)SC
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| InChI |
1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26)
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| InChIKey |
VAARYSWULJUGST-UHFFFAOYSA-N
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| CAS Number |
CAS 260415-63-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
826288, 4331030, 7889655, 8036145, 10300001, 14808210, 36889328, 46504639, 49742602, 57404785, 78008929, 103499403, 104637464, 134344076, 136367837, 137184828, 143220966, 143499564, 144116346, 152234888, 160965748, 162205113, 165245608, 174006563, 174561029, 178102326, 186000989, 226605415, 242059912, 243077787, 252216013, 252435738, 252543332
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| ChEBI ID |
CHEBI:49791
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5699). | |||
| REF 2 | Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. | |||
| REF 3 | Structural insights into the ATP binding pocket of the anaplastic lymphoma kinase by site-directed mutagenesis, inhibitor binding analysis, and hom... J Med Chem. 2006 Sep 21;49(19):5759-68. | |||
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