Drug Information
Drug General Information | Top | |||
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Drug ID |
D03IUD
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Former ID |
DIB013340
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Drug Name |
Ceftolozane sulfate
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Synonyms |
Ceftolozane; CXA-101; CXA-301; CXA-301); Cephalosporin derivatives, Astellas; Cephalosporinderivatives, Calixa Therapeutics; FR-193879; FR-264205; FR-295389; CXA-101 (inhaled), Calixa; CXA-101 (inhaled), Cubist; Cephalosporin derivative (H pylori/P aeruginosa infection), Astellas; CXA-101 (inhaled, bacterial lung infection), Cubist
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Drug Type |
Small molecular drug
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Indication | Respiratory tract infection [ICD-11: CA45; ICD-10: J13, J15] | Phase 4 | [1] | |
Company |
Fujisawa Pharmaceutical Co Ltd; Calixa Therapeutics Inc
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Structure |
Download2D MOL
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Formula |
C23H32N12O12S3
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Canonical SMILES |
CC(C)(C(=O)O)ON=C(C1=NSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC(=C(N4C)N)NC(=O)NCCN)C(=O)O.OS(=O)(=O)[O-]
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InChI |
1S/C23H30N12O8S2.H2O4S/c1-23(2,20(40)41)43-31-11(15-30-21(26)45-32-15)16(36)29-12-17(37)35-13(19(38)39)9(8-44-18(12)35)6-34-7-10(14(25)33(34)3)28-22(42)27-5-4-24;1-5(2,3)4/h7,12,18,25H,4-6,8,24H2,1-3H3,(H7,26,27,28,29,30,32,36,38,39,40,41,42);(H2,1,2,3,4)/b31-11+;/t12-,18-;/m1./s1
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InChIKey |
UJDQGRLTPBVSFN-GZGOMJRCSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Bacterial Penicillin binding protein (Bact PBP) | Target Info | Modulator | [2] |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT02421120) Population Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Adult Cystic Fibrosis Patients. U.S. National Institutes of Health. | |||
REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. |
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