Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03HDV
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| Former ID |
DIB014190
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| Drug Name |
DWP-431
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| Synonyms |
Recombinant bone morphogenetic protein 2 (bone synthesis), Daewoong; RBMP-2 (bone synthesis), Daewoong
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| Indication | Bone development disorder [ICD-11: FB86] | Phase 3 | [1] | |
| Company |
Daewoong Pharmaceutical Co Ltd
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bone morphogenetic protein 2 (BMP2) | Target Info | Modulator | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Hedgehog signaling pathway | ||||
| TGF-beta signaling pathway | ||||
| Hippo signaling pathway | ||||
| Signaling pathways regulating pluripotency of stem cells | ||||
| Pathways in cancer | ||||
| Basal cell carcinoma | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| IL4 Signaling Pathway | ||||
| RANKL Signaling Pathway | ||||
| Panther Pathway | TGF-beta signaling pathway | |||
| Pathway Interaction Database | BMP receptor signaling | |||
| Reactome | Molecules associated with elastic fibres | |||
| WikiPathways | Senescence and Autophagy in Cancer | |||
| Differentiation of white and brown adipocyte | ||||
| Signaling by BMP | ||||
| Elastic fibre formation | ||||
| BDNF signaling pathway | ||||
| Adipogenesis | ||||
| Heart Development | ||||
| BMP Signalling and Regulation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01634308) Efficacy and Safety of Bongros-BMP Compared to Bio-oss for Regeneration of Alveolar Bone Tissue After Maxillary Sinus Floor Augmentation. U.S. National Institutes of Health. | |||
| REF 2 | Complications with the use of bone morphogenetic protein 2 (BMP-2) in spine surgery. Spine J. 2014 Mar 1;14(3):552-9. | |||
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