Drug Information

Drug General Information

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Drug ID

D03GWY

Former ID

DNC000431

Drug Name

Ciglitazone

Synonyms

ciglitazone; 74772-77-3; Ciglitizone; ADD-3878; Ciglitazonum; Ciglitazona; Ciglitazonum [Latin]; Ciglitazona [Spanish]; Ciglitazone [USAN:INN]; ADD 3878; CHEBI:64227; U-63287; (+-)-5-(p-((1-Methylcyclohexyl)methoxy)benzyl)-2,4-thiazolidinedione; C18H23NO3S; 5-(4-((1-methylcyclohexyl)methoxy)benzyl)thiazolidine-2,4-dione; YZFWTZACSRHJQD-UHFFFAOYSA-N; (+/-)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione; U 63287; 5-{4-[(1-methylcyclohexyl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione; NCGC00164446-01

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Drug Type

Small molecular drug

Indication

Pulmonary fibrosis [ICD-11: CB03.4; ICD-10: J84.1]

Preclinical

[1]

Structure

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2D MOL

3D MOL

Formula

C18H23NO3S

Canonical SMILES

CC1(CCCCC1)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3

InChI

1S/C18H23NO3S/c1-18(9-3-2-4-10-18)12-22-14-7-5-13(6-8-14)11-15-16(20)19-17(21)23-15/h5-8,15H,2-4,9-12H2,1H3,(H,19,20,21)

InChIKey

YZFWTZACSRHJQD-UHFFFAOYSA-N

CAS Number

CAS 74772-77-3

PubChem Compound ID

2750

PubChem Substance ID

6897912, 7978942, 8151777, 11120025, 11120513, 11121001, 11121640, 11122120, 11147108, 11362709, 11365271, 11367833, 11370689, 11370690, 11373434, 11375995, 12012730, 14899936, 17397629, 22391558, 24892661, 26681499, 26752160, 26752161, 26752162, 26757865, 26758470, 29221905, 46488049, 47216537, 47810501, 48110200, 48334208, 50052262, 50104808, 50620095, 53788148, 56312056, 56314037, 57321433, 85788733, 91611856, 92309991, 95612759, 99300903, 99302423, 103165086, 103853966, 104046501, 104301499

ChEBI ID

CHEBI:64227

Target and Pathway

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Target(s)

Peroxisome proliferator-activated receptor gamma (PPAR-gamma)

Target Info

Agonist

[2]

KEGG Pathway

PPAR signaling pathway

AMPK signaling pathway