Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00YWL
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| Former ID |
DIB001371
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| Drug Name |
BMS-936557
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| Synonyms |
Anti-CXCL10 antibody (iv, ulcerative colitis/ rheumatoid arthritis/ inflammation), Medarex/BMS; Anti-IP-10 antibody (iv, ulcerative colitis/ rheumatoid arthritis/ inflammation), Bristol-Myers Squibb/Medarex
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| Drug Type |
Antibody
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| Indication | Immune System disease [ICD-11: 4A01-4B41; ICD-10: D80-D89] | Phase 2 | [1] | |
| Company |
Medarex Inc
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | C-X-C motif chemokine 10 (CXCL10) | Target Info | . | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Chemokine signaling pathway | ||||
| Toll-like receptor signaling pathway | ||||
| RIG-I-like receptor signaling pathway | ||||
| Cytosolic DNA-sensing pathway | ||||
| TNF signaling pathway | ||||
| Influenza A | ||||
| NetPath Pathway | IL-7 Signaling Pathway | |||
| TSLP Signaling Pathway | ||||
| TNFalpha Signaling Pathway | ||||
| TWEAK Signaling Pathway | ||||
| TCR Signaling Pathway | ||||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| Pathway Interaction Database | CXCR3-mediated signaling events | |||
| Reactome | Chemokine receptors bind chemokines | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Toll-like receptor signaling pathway | |||
| Type II interferon signaling (IFNG) | ||||
| Spinal Cord Injury | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Regulation of toll-like receptor signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01466374) Induction and Maintenance Study of BMS-936557 in Patients With Moderate to Severely Active Crohn's Disease. U.S. National Institutes of Health. | |||
| REF 2 | Anti-IP-10 antibody (BMS-936557) for ulcerative colitis: a phase II randomised study. Gut. 2014 Mar;63(3):442-50. | |||
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