Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00TBD
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| Former ID |
DIB009573
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| Drug Name |
PHA-665752
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| Synonyms |
PHA-665752; 477575-56-7; PHA 665752; PHA665752; TCMDC-125885; UNII-0VXU5T5R3J; (2R)-1-[[5-[(Z)-[5-[[(2,6-DICHLOROPHENYL)METHYL]SULFONYL]-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE]METHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL]CARBONYL]-2-(1-PYRROLIDINYLMETHYL)PYRROLIDINE; 0VXU5T5R3J; CHEMBL450786; CHEBI:90197; (R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one; PHA-665752 hydrate
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Investigative | [1] | |
| Company |
Pfizer Inc
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| Structure |
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Download2D MOL |
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| Formula |
C32H34Cl2N4O4S
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| Canonical SMILES |
CC1=C(NC(=C1C(=O)N2CCCC2CN3CCCC3)C)C=C4C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O
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| InChI |
1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1
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| InChIKey |
OYONTEXKYJZFHA-SSHUPFPWSA-N
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| CAS Number |
CAS 477575-56-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
15483678, 22395877, 22794587, 40589429, 56365801, 57374776, 80743386, 85788221, 85860340, 99373534, 99436966, 103583760, 104099202, 123044255, 124756977, 125163782, 126579152, 126634884, 126666967, 126726473, 134964501, 135653699, 135698633, 136340173, 136345872, 136367825, 140211271, 152036097, 152258323, 152344012, 160647162, 162011397, 162023531, 162038091, 163685974, 165246671, 172650123, 174529205, 176245453, 178102327, 179696633, 184828427, 198988542, 223386032, 223670959, 226471400, 241083985, 242059929, 251970987, 252156718
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| ChEBI ID |
CHEBI:90197
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5700). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). | |||
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