Drug Information
Drug General Information | Top | |||
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Drug ID |
D00LYI
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Former ID |
DNC005943
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Drug Name |
Meta-sirtinol
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C26H22N2O2
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Canonical SMILES |
CC(C1=CC=CC=C1)NC(=O)C2=CC(=CC=C2)N=CC3=C(C=CC4=CC=CC=C43)O
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InChI |
1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)28-26(30)21-11-7-12-22(16-21)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,29H,1H3,(H,28,30)
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InChIKey |
USDKSBHPFQRCGR-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | NAD-dependent deacetylase sirtuin-1 (SIRT1) | Target Info | Inhibitor | [1] |
KEGG Pathway | FoxO signaling pathway | |||
AMPK signaling pathway | ||||
Glucagon signaling pathway | ||||
Amphetamine addiction | ||||
MicroRNAs in cancer | ||||
Panther Pathway | p53 pathway | |||
Pathway Interaction Database | p73 transcription factor network | |||
Signaling events mediated by HDAC Class III | ||||
E2F transcription factor network | ||||
HIF-2-alpha transcription factor network | ||||
Signaling events mediated by HDAC Class I | ||||
FoxO family signaling | ||||
Regulation of Androgen receptor activity | ||||
Regulation of retinoblastoma protein | ||||
Reactome | RORA activates gene expression | |||
Regulation of HSF1-mediated heat shock response | ||||
Circadian Clock | ||||
WikiPathways | Integrated Pancreatic Cancer Pathway | |||
SREBF and miR33 in cholesterol and lipid homeostasis | ||||
Integrated Breast Cancer Pathway | ||||
SREBP signalling | ||||
Androgen receptor signaling pathway |
References | Top | |||
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REF 1 | Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1;48(24):7789-95. |
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