Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
DYSA16
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| Drug Name |
RT-400
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| Synonyms |
JNJ-39588146
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| Drug Type |
Peptide
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| Indication | Acute decompensated heart failure [ICD-11: BD1Z; ICD-10: I50, I50.9; ICD-9: 428] | Phase 2 | [1] | |
| Company |
Renova Therapeutics
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Corticotropin-releasing factor receptor 2 (CRHR2) | Target Info | Agonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Panther Pathway | Cortocotropin releasing factor receptor signaling pathway | |||
| Reactome | Class B/2 (Secretin family receptors) | |||
| G alpha (s) signalling events | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Corticotropin-releasing hormone | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Advances in therapeutic peptides targeting G protein-coupled receptors. Nat Rev Drug Discov. 2020 Jun;19(6):389-413. | |||
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