Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
DURD59
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| Drug Name |
SPR720
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| Synonyms |
UNII-1NL76YUU6E; 1NL76YUU6E; CHEMBL2221212; VXC-486 phosphate; SCHEMBL10323399; BDBM50112815; ZINC95566061; HY-135655A; CS-0127906; 1384984-31-9; 2-[5-[2-(ethylcarbamoylamino)-6-fluoro-7-[(2R)-oxolan-2-yl]-3H-benzimidazol-5-yl]pyrimidin-2-yl]propan-2-yl dihydrogen phosphate; N-Ethyl-N'-(6-fluoro-5-(2-(1-methyl-1-(phosphonooxy)ethyl)-5-pyrimidinyl)-7-((2R)-tetrahydro-2-furanyl)-1H-benzimidazol-2-yl)urea; Urea, N-ethyl-N'-(6-fluoro-5-(2-(1-methyl-1-(phosphonooxy)ethyl)-5-pyrimidinyl)-7-((2R)-tetrahydro-2-furanyl)-1H-benzimidazol-2-yl)-
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| Drug Type |
Small molecular drug
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| Indication | Mycobacterium infection [ICD-11: 1B10-1B21] | Phase 1/2 | [1] | |
| Company |
Spero Therapeutics
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H26FN6O6P
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| Canonical SMILES |
CCNC(=O)NC1=NC2=C(N1)C=C(C(=C2C3CCCO3)F)C4=CN=C(N=C4)C(C)(C)OP(=O)(O)O
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| InChI |
1S/C21H26FN6O6P/c1-4-23-20(29)28-19-26-13-8-12(16(22)15(17(13)27-19)14-6-5-7-33-14)11-9-24-18(25-10-11)21(2,3)34-35(30,31)32/h8-10,14H,4-7H2,1-3H3,(H2,30,31,32)(H3,23,26,27,28,29)/t14-/m1/s1
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| InChIKey |
COTQDURISRILOR-CQSZACIVSA-N
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| CAS Number |
CAS 1384984-31-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial DNA gyrase B (Bact gyrB) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04553406) Phase 2a Safety, Tolerability, Pharmacokinetics and Efficacy of SPR720 for the Treatment of Patients With Mycobacterium Avium Complex (MAC) Pulmonary Disease. U.S. National Institutes of Health. | |||
| REF 2 | Advancement of GyrB Inhibitors for Treatment of Infections Caused by Mycobacterium tuberculosis and Non-tuberculous Mycobacteria. ACS Infect Dis. 2020 Jun 12;6(6):1323-1331. | |||
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