Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DTO06Y
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| Drug Name |
Macozinone
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| Synonyms |
PBTZ169; 1377239-83-2; PBTZ-169; 2-(4-(cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one; UNII-A3M1353L40; A3M1353L40; 2-[4-(cyclohexylmethyl)piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one; 4H-1,3-Benzothiazin-4-one, 2-(4-(cyclohexylmethyl)-1-piperazinyl)-8-nitro-6-(trifluoromethyl)-; 4H-1,3-Benzothiazin-4-one, 2-[4-(cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-; Macozinone [INN]; SCHEMBL6128230; CHEMBL3330226; BTZ-169; PBTZ 169;PBTZ-169; BCP18094; EX-A1013; PBTZ-169;PBTZ 169;Macozinone; BDBM50515570; MFCD28902203; s6549; AKOS030526001; ZINC141433347; CS-5777; DB14821; SB19755; YH65042; BS-15317; HY-12903; DS-015880; 2-(4-(Cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-trifluoromethyl-4H-1,3-benzothiazin-4-one
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| Drug Type |
Small molecular drug
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| Indication | Mycobacterium infection [ICD-11: 1B10-1B21] | Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C20H23F3N4O3S
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| Canonical SMILES |
C1CCC(CC1)CN2CCN(CC2)C3=NC(=O)C4=C(S3)C(=CC(=C4)C(F)(F)F)[N+](=O)[O-]
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| InChI |
1S/C20H23F3N4O3S/c21-20(22,23)14-10-15-17(16(11-14)27(29)30)31-19(24-18(15)28)26-8-6-25(7-9-26)12-13-4-2-1-3-5-13/h10-11,13H,1-9,12H2
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| InChIKey |
BJDZBXGJNBMCAV-UHFFFAOYSA-N
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| CAS Number |
CAS 1377239-83-2
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Mycobacterium Decaprenylphosphoryl-beta-D-ribose oxidase (McyB dprE1) | Target Info | Inhibitor | [2] |
| References | Top | |||
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| REF 1 | ClinicalTrials.gov (NCT04150224) Safety, Tolerability, Pharmacokinetics and Food Effects Study of PBTZ169. U.S. National Institutes of Health. | |||
| REF 2 | Spirocyclic and Bicyclic 8-Nitrobenzothiazinones for Tuberculosis with Improved Physicochemical and Pharmacokinetic Properties. ACS Med Chem Lett. 2019 Feb 23;10(3):348-351. | |||
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