Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
DT7I5A
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| Drug Name |
N-803
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| Synonyms |
Anktiva; ALT-803
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| Drug Type |
Recombinant protein
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| Indication | Human immunodeficiency virus infection [ICD-11: 1C62] | Phase 1 | [1] | |
| Company |
ImmunityBio
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Interleukin-15 (IL15) | Target Info | Agonist | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Jak-STAT signaling pathway | ||||
| TNF signaling pathway | ||||
| Intestinal immune network for IgA production | ||||
| HTLV-I infection | ||||
| Herpes simplex infection | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| FSH Signaling Pathway | ||||
| Leptin Signaling Pathway | ||||
| Panther Pathway | Interleukin signaling pathway | |||
| WikiPathways | Cytokines and Inflammatory Response | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04808908) Effect of N-803 on B Cell Follicles in Antiretroviral Treated HIV Disease. U.S. National Institutes of Health. | |||
| REF 2 | The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques. PLoS Pathog. 2020 Mar 12;16(3):e1008339. | |||
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