Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DSEP59
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| Drug Name |
PF-07059013
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| Synonyms |
PF-07059013; 6-{(1S)-1-[(2-amino-6-fluoroquinolin-3-yl)oxy]ethyl}-5-(1H-pyrazol-1-yl)pyridin-2(1H)-one; 2435610-93-6; 6-((1S)-1-((2-Amino-6-fluoroquinolin-3-yl)oxy)ethyl)-5-(1H-pyrazol-1-yl)pyridin-2(1H)-one; FXK42BP3GL; CHEMBL4650304; SCHEMBL21988630; GTPL12786; BDBM50565929; compound 23 [PMID: 33356244]; HY-139293; CS-0188516; PF07059013; 6-[(1S)-1-(2-amino-6-fluoroquinolin-3-yl)oxyethyl]-5-pyrazol-1-yl-1H-pyridin-2-one; (S)-6-(1-((2-Amino-6-fluoroquinolin-3-yl)oxy)ethyl)-5-(1H-pyrazol-1-yl)pyridin-2(1H)-one; 2(1H)-Pyridinone, 6-((1S)-1-((2-amino-6-fluoro-3-quinolinyl)oxy)ethyl)-5-(1H-pyrazol-1-yl)-; VUD
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| Drug Type |
Small molecule
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| Indication | Sickle-cell disorder [ICD-11: 3A51; ICD-10: D57, D57.8; ICD-9: 282.5, 282.6] | Phase 1 | [1] | |
| Company |
Pfizer
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| Structure |
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Download2D MOL |
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| Formula |
C19H16FN5O2
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| Canonical SMILES |
CC(C1=C(C=CC(=O)N1)N2C=CC=N2)OC3=C(N=C4C=CC(=CC4=C3)F)N
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| InChI |
InChI=1S/C19H16FN5O2/c1-11(18-15(5-6-17(26)24-18)25-8-2-7-22-25)27-16-10-12-9-13(20)3-4-14(12)23-19(16)21/h2-11H,1H3,(H2,21,23)(H,24,26)/t11-/m0/s1
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| InChIKey |
CLEFVPILGAPOTG-NSHDSACASA-N
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04323124) A PHASE 1, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, SINGLE AND MULTIPLE DOSE ESCALATION STUDY TO EVALUATE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF PF-07059013 AND OPEN-LABEL ASSESSMENT OF FOOD AND FORMULATION ON PHARMACOKINETICS OF PF-07059013 IN HEALTHY ADULT PARTICIPANTS. U.S.National Institutes of Health. | |||
| REF 2 | PF-07059013: A non-covalent hemoglobin modulator favorably impacts disease state in a mouse model of sickle cell disease. Am J Hematol. 2021 Aug 1;96(8):E272-E275. | |||
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