Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DS19UZ
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| Drug Name |
Savirin
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| Synonyms |
3-(4-propan-2-ylphenyl)sulfonyl-1H-triazolo[1,5-a]quinazolin-5-one; 866350-26-7; 3-[(4-isopropylphenyl)sulfonyl][1,2,3]triazolo[1,5-a]quinazolin-5(4H)-one; 3-[4-(propan-2-yl)benzenesulfonyl]-4H,5H-[1,2,3]triazolo[1,5-a]quinazolin-5-one; SMR000016143; MLS000103489; MLS000044860; CHEMBL1494499; CHEBI:107601; HMS2494G18; ZINC8762827; CCG-27345; HTS003632; MFCD05899664; STL094729; AKOS005723252; BS-6686; MCULE-8359721687; UNM000011043901; SR-01000104752; SR-01000104752-1; Q27185926; 3-{[4-(propan-2-yl)phenyl]sulfonyl}[1,2,3]triazolo[1,5-a]quinazolin-5(4H)-one
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| Drug Type |
Small molecular drug
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| Indication | Staphylococcus infection [ICD-11: 1B5Y; ICD-10: A49.0; ICD-9: 001-139] | Preclinical | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C18H16N4O3S
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| Canonical SMILES |
CC(C)C1=CC=C(C=C1)S(=O)(=O)C2=NNN3C2=NC(=O)C4=CC=CC=C43
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| InChI |
1S/C18H16N4O3S/c1-11(2)12-7-9-13(10-8-12)26(24,25)18-16-19-17(23)14-5-3-4-6-15(14)22(16)21-20-18/h3-11,21H,1-2H3
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| InChIKey |
GIFXGSITUBUVGH-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:107601
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Staphylococcus Accessory gene regulator protein A (Stap-coc agrA) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Rev Drug Discov. 2017 Jul;16(7):457-471. | |||
| REF 2 | Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. PLoS Pathog. 2014 Jun 12;10(6):e1004174. | |||
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