Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DRL76S
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| Drug Name |
AMXT1501
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| Synonyms |
(S)-N-(5-Amino-6-((3-((4-((3-aminopropyl)amino)butyl)amino)propyl)amino)-6-oxohexyl)palmitamide; 441022-64-6; CHEMBL474784; SCHEMBL10033849; N-(N6-Palmitoyl-L-lysyl)-4,9-diazadodecane-1,12-diamine
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199] | Phase 1 | [1] | |
| Company |
Aminex Therapeutics
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| Structure |
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Download2D MOL
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| Formula |
C32H68N6O2
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| Canonical SMILES |
CCCCCCCCCCCCCCCC(=O)NCCCCC(C(=O)NCCCNCCCCNCCCN)N
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| InChI |
1S/C32H68N6O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-22-31(39)37-28-16-15-21-30(34)32(40)38-29-20-27-36-25-18-17-24-35-26-19-23-33/h30,35-36H,2-29,33-34H2,1H3,(H,37,39)(H,38,40)/t30-/m0/s1
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| InChIKey |
USNCWPSRPOWEBG-PMERELPUSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polyamine transport (Poly trans) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT03536728) Oral AMXT 1501 Dicaprate in Combination With DFMO. U.S. National Institutes of Health. | |||
| REF 2 | AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport. Int J Cancer. 2013 Sep 15;133(6):1323-33. | |||
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