Drug Information
Drug General Information | Top | |||
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Drug ID |
DR8CM0
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Drug Name |
MK-3655
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Drug Type |
Monoclonal antibody
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Indication | Non-alcoholic steatohepatitis [ICD-11: DB92.1; ICD-10: K75.8; ICD-9: 571.8] | Phase 2 | [1] | |
Company |
Merck
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Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Beta-klotho (KLB) | Target Info | . | [2] |
Fibroblast growth factor receptor 1 (FGFR1) | Target Info | . | [2] | |
KEGG Pathway | MAPK signaling pathway | |||
Ras signaling pathway | ||||
Rap1 signaling pathway | ||||
PI3K-Akt signaling pathway | ||||
Adherens junction | ||||
Signaling pathways regulating pluripotency of stem cells | ||||
Regulation of actin cytoskeleton | ||||
Pathways in cancer | ||||
Proteoglycans in cancer | ||||
Prostate cancer | ||||
Melanoma | ||||
Central carbon metabolism in cancer | ||||
NetPath Pathway | TCR Signaling Pathway | |||
Panther Pathway | Angiogenesis | |||
FGF signaling pathway | ||||
Pathway Interaction Database | Glypican 1 network | |||
Syndecan-4-mediated signaling events | ||||
N-cadherin signaling events | ||||
FGF signaling pathway | ||||
WikiPathways | Regulation of Actin Cytoskeleton | |||
Endochondral Ossification | ||||
MAPK Signaling Pathway | ||||
Mesodermal Commitment Pathway | ||||
Hair Follicle Development: Induction (Part 1 of 3) | ||||
Integrated Pancreatic Cancer Pathway | ||||
Signaling Pathways in Glioblastoma | ||||
Neural Crest Differentiation | ||||
Signaling by FGFR |
References | Top | |||
---|---|---|---|---|
REF 1 | ClinicalTrials.gov (NCT04583423) A Phase 2b Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-3655 in Individuals With Pre-cirrhotic Nonalcoholic Steatohepatitis. U.S.National Institutes of Health. | |||
REF 2 | Non-Alcoholic Steatohepatitis (NASH) - A Review of a Crowded Clinical Landscape, Driven by a Complex Disease. Drug Des Devel Ther. 2021 Sep 22;15:3997-4009. |
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