Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DP6Y5N
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| Drug Name |
MK-8719
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| Synonyms |
1382799-40-7; (3aR,5S,6S,7R,7aR)-5-(difluoromethyl)-2-(ethylamino)-3a,6,7,7a-tetrahydro-5H-pyrano[3,2-d]thiazole-6,7-diol; (3aR,5S,6S,7R,7aR)-5-(difluoromethyl)-2-(ethylamino)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol; SCHEMBL9956073; CHEMBL4111094; GTPL10508; BDBM205424; MK8719; s8890; compound 42 [PMID: 31487175]; US9243020, 19; Q66885447; (3aR,5S,6S,7R,7aR)-5-(difluoromethyl)-2-ethylimino-1,3a,5,6,7,7a-hexahydropyrano[3,2-d][1,3]thiazole-6,7-diol; (3AR,5S,6S,7R,7aR,E)-5-(difluoromethyl)-2-(ethylimino)hexahydro-5H-pyrano[3,2-d]thiazole-6,7-diol
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| Drug Type |
Small molecular drug
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| Indication | Progressive supranuclear palsy [ICD-11: 8A00.10; ICD-10: G23.1] | Phase 1 | [1] | |
| Company |
Alectos
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| Structure |
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Download2D MOL |
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| Formula |
C9H14F2N2O3S
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| Canonical SMILES |
CCN=C1NC2C(C(C(OC2S1)C(F)F)O)O
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| InChI |
1S/C9H14F2N2O3S/c1-2-12-9-13-3-4(14)5(15)6(7(10)11)16-8(3)17-9/h3-8,14-15H,2H2,1H3,(H,12,13)/t3-,4-,5+,6+,8-/m1/s1
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| InChIKey |
UDQTXCHQKHIQMH-KYGLGHNPSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Beta-N-acetylhexosaminidase (OGA) | Target Info | Inhibitor | [1] |
| References | Top | |||
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| REF 1 | Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Nov 27;62(22):10062-10097. | |||
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