Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DP3J2W
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| Drug Name |
UPF-648
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| Synonyms |
213400-34-1; (1s,2s)-2-(3,4-Dichlorobenzoyl)cyclopropanecarboxylic Acid; UPF 648; CHEMBL3407929; (1S,2S)-2-(3,4-DICHLOROBENZOYL)CYCLOPROPANE-1-CARBOXYLIC ACID; DBCC; SCHEMBL5310798; BDBM50072083; ZINC33994919; AKOS027470152; CS-3567; HY-15600; Q27452085; (1s,2s)-2-(3,4-dichlorobenzoyl)-cyclopropane-1-carboxylic acid; (1S,2S)-2-[(3,4-dichlorophenyl)carbonyl]cyclopropane-1-carboxylic acid; 1HR
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| Drug Type |
Small molecular drug
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| Indication | Neurodegenerative disorder [ICD-11: 8A20-8A23] | Preclinical | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H8Cl2O3
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| Canonical SMILES |
C1C(C1C(=O)O)C(=O)C2=CC(=C(C=C2)Cl)Cl
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| InChI |
1S/C11H8Cl2O3/c12-8-2-1-5(3-9(8)13)10(14)6-4-7(6)11(15)16/h1-3,6-7H,4H2,(H,15,16)/t6-,7-/m0/s1
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| InChIKey |
ZBRKMOHDGFGXLN-BQBZGAKWSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Kynurenine 3-hydroxylase (KMO) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401. | |||
| REF 2 | Structural basis of kynurenine 3-monooxygenase inhibition. Nature. 2013 Apr 18;496(7445):382-5. | |||
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