Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DMQ86J
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| Drug Name |
QPX7728
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| Synonyms |
Xeruborbactam; Xeruborbactam [INN]; 2170834-63-4; DE79L822UY; UNII-DE79L822UY; CHEMBL4633785; Benzo(E)cycloprop(C)(1,2)oxaborin-4-carboxylic acid, 5-fluoro-1,1a,2,7B-tetrahydro-2-hydroxy-, (1aR,7bS)-; QPX7728; EX-A7712; QPX-7728; BDBM50541448; AKOS040735994; PD193971; HY-136069; CS-0119486
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| Drug Type |
Small molecule
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Phase 1 | [1] | |
| Company |
Qpex Biopharma
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| Structure |
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Download2D MOL
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| Formula |
C10H8BFO4
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| Canonical SMILES |
B1(C2CC2C3=C(O1)C(=C(C=C3)F)C(=O)O)O
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| InChI |
InChI=1S/C10H8BFO4/c12-7-2-1-4-5-3-6(5)11(15)16-9(4)8(7)10(13)14/h1-2,5-6,15H,3H2,(H,13,14)/t5-,6-/m1/s1
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| InChIKey |
KOHUFVUIYUCFNG-PHDIDXHHSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Staphylococcus Beta-lactamase (Stap-coc blaZ) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT05072444) A Phase 1, Randomized, Double-Blind, Single-Dose, Drug-Drug Interaction Study to Determine the Impact of Co-administration of QPX7728 on the Pharmacokinetics of QPX2014 in Healthy Adult Subjects. U.S.National Institutes of Health. | |||
| REF 2 | QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics. Front Microbiol. 2021 Jul 5;12:697180. | |||
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